RNA modification is manifested as chemically altered nucleotides, widely exists in diverse
natural RNAs, and is closely related to RNA structure and function. Currently, mRNA-based …

In 2018, LNPs enabled the first FDA approval of a siRNA drug (Onpattro); two years later,
two SARS-CoV-2 vaccines (Comirnaty, Spikevax) based on LNPs containing mRNA also …

The evolutionary conserved CCR4-NOT complex functions in the cytoplasm as the main
mRNA deadenylase in both constitutive mRNA turnover and regulated mRNA decay …

Resource competition can be the cause of unintended coupling between co-expressed
genetic constructs. Here we report the quantification of the resource load imposed by …

The polymerase-associated factor 1 (Paf1) complex (Paf1C) is a conserved protein complex
with critical functions during eukaryotic transcription. Previous studies showed that Paf1C is …

Single-stranded RNA (ssRNA) plays a major role in the flow of genetic information–most
notably, in the form of messenger RNA (mRNA)–and in the regulation of biological …

Pancreatic ductal adenocarcinoma (PDAC) is extremely malignant with limited treatment
options. Deubiquitinases (DUBs), which cleave ubiquitin on substrates, can regulate tumor …

In eukaryotes, mRNA metabolism requires a sophisticated signaling system. Recent studies
have suggested that polyadenylate tail may play a vital role in such a system. The poly (A) …

Owing to their outstanding performance against COVID-19, mRNA vaccines have brought
great hope for combating various incurable diseases, including cancer. Differences in the …

Abstract Growth differentiation factor 15 (GDF-15) is a cytokine that is widely used as a
biomarker for the severity of diverse disease states. It also has been shown to play a …