Traumatic brain injuries (TBIs) account for the majority of injury-related deaths in the United
States with roughly two million TBIs occurring annually. Due to the spectrum of severity and …

The Blood Brain Barrier (BBB) is a specialized vascular structure tightly regulating central
nervous system (CNS) homeostasis. Endothelial cells are the central component of the BBB …

Eph receptors are the largest family of receptor tyrosine kinases and mediate a myriad of
essential processes in humans from embryonic development to adult tissue homeostasis …

Preclinical studies have suggested that platelets influence the host response during sepsis.
We sought to assess the association of admission thrombocytopenia with the presentation …

BACKGROUND Human pregnancy requires robust hemostasis to prevent hemorrhage
during extravillous trophoblast (EVT) invasion of the decidualized endometrium, modification …

The angiopoietin (Ang)–Tie ligand–receptor system has a key regulatory role in regulating
vascular integrity and quiescence. Besides its role in angiogenesis, it is an important …

The receptor tyrosine kinase Tie2, and its activating ligand Angiopoietin-1 (Ang1), are
required for vascular remodelling and vessel integrity, whereas Ang2 may counteract these …

The blood–brain barrier (BBB) constitutes an elaborate structure formed by specialized
capillary endothelial cells, which together with pericytes and perivascular glial cells …

Bone marrow stromal cells (MSCs) increase vascular endothelial growth factor (VEGF)
expression and promote angiogenesis after stroke. Angiopoietin-1 (Ang1) and its receptor …

Purpose: The blood vessel-destabilizing Tie2 ligand angiopoietin-2 (Ang-2) acts in concert
with the vascular endothelial growth factor/vascular endothelial growth factor receptor …