Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications

Z Yan, B Rein - Molecular psychiatry, 2022 - nature.com
The prefrontal cortex (PFC) serves as the chief executive officer of the brain, controlling the
highest level cognitive and emotional processes. Its local circuits among glutamatergic …

Neural basis of prosocial behavior

YE Wu, W Hong - Trends in Neurosciences, 2022 - cell.com
The ability to behave in ways that benefit other individuals' well-being is among the most
celebrated human characteristics crucial for social cohesiveness. Across mammalian …

Cortical astrocytes modulate dominance behavior in male mice by regulating synaptic excitatory and inhibitory balance

K Noh, WH Cho, BH Lee, DW Kim, YS Kim, K Park… - Nature …, 2023 - nature.com
Social hierarchy is established as an outcome of individual social behaviors, such as
dominance behavior during long-term interactions with others. Astrocytes are implicated in …

Convergent molecular, cellular, and cortical neuroimaging signatures of major depressive disorder

KM Anderson, MA Collins, R Kong… - Proceedings of the …, 2020 - National Acad Sciences
Major depressive disorder emerges from the complex interactions of biological systems that
span genes and molecules through cells, networks, and behavior. Establishing how …

Beyond the three-chamber test: toward a multimodal and objective assessment of social behavior in rodents

R Jabarin, S Netser, S Wagner - Molecular Autism, 2022 - Springer
Main In recent years, substantial advances in social neuroscience have been realized,
including the generation of numerous rodent models of autism spectrum disorder. Still, it can …

Reciprocal cortico-amygdala connections regulate prosocial and selfish choices in mice

D Scheggia, F La Greca, F Maltese… - Nature …, 2022 - nature.com
Decisions that favor one's own interest versus the interest of another individual depend on
context and the relationships between individuals. The neurobiology underlying selfish …

Top-down control of hippocampal signal-to-noise by prefrontal long-range inhibition

R Malik, Y Li, S Schamiloglu, VS Sohal - Cell, 2022 - cell.com
Prefrontal cortex (PFC) is postulated to exert" top-down control" on information processing
throughout the brain to promote specific behaviors. However, pathways mediating top-down …

Dynamics of a disinhibitory prefrontal microcircuit in controlling social competition

C Zhang, H Zhu, Z Ni, Q Xin, T Zhou, R Wu, G Gao… - Neuron, 2022 - cell.com
Social competition plays a pivotal role in determining individuals' social status. While the
dorsomedial prefrontal cortex (dmPFC) is essential in regulating social competition, it …

The medial prefrontal cortex as a central hub for mental comorbidities associated with chronic pain

KK Kummer, M Mitrić, T Kalpachidou… - International journal of …, 2020 - mdpi.com
Chronic pain patients frequently develop and suffer from mental comorbidities such as
depressive mood, impaired cognition, and other significant constraints of daily life, which …

[HTML][HTML] Neural mechanisms necessary for empathy-related phenomena across species

E Paradiso, V Gazzola, C Keysers - Current opinion in neurobiology, 2021 - Elsevier
The neural basis of empathy and prosociality has received much interest over the past
decades. Neuroimaging studies localized a network of brain regions with activity that …