[HTML][HTML] The scaffold-forming steps of plant alkaloid biosynthesis

BR Lichman - Natural Product Reports, 2021 - pubs.rsc.org
Alkaloids from plants are characterised by structural diversity and bioactivity, and maintain a
privileged position in both modern and traditional medicines. In recent years, there have …

l‐lysine metabolism to N‐hydroxypipecolic acid: an integral immune‐activating pathway in plants

M Hartmann, J Zeier - The Plant Journal, 2018 - Wiley Online Library
Summary l‐lysine catabolic routes in plants include the saccharopine pathway to α‐
aminoadipate and decarboxylation of lysine to cadaverine. The current review will cover a …

A metabolic regulon reveals early and late acting enzymes in neuroactive Lycopodium alkaloid biosynthesis

RS Nett, Y Dho, YY Low… - Proceedings of the …, 2021 - National Acad Sciences
Plants synthesize many diverse small molecules that affect function of the mammalian
central nervous system, making them crucial sources of therapeutics for neurological …

[HTML][HTML] Plant carbonic anhydrase-like enzymes in neuroactive alkaloid biosynthesis

RS Nett, Y Dho, C Tsai, D Passow… - Nature, 2023 - nature.com
Plants synthesize numerous alkaloids that mimic animal neurotransmitters. The diversity of
alkaloid structures is achieved through the generation and tailoring of unique carbon …

Subcellular compartmentalization in the biosynthesis and engineering of plant natural produces

L Yao, X Wu, X Jiang, M Shan, Z Zhang, Y Li… - Biotechnology …, 2023 - Elsevier
Plant natural products (PNPs) are specialized metabolites with diverse bioactivities. They
are extensively used in the pharmaceutical, cosmeceutical and food industries. PNPs are …

Unveiling of swainsonine biosynthesis via a multibranched pathway in fungi

F Luo, S Hong, B Chen, Y Yin, G Tang, F Hu… - ACS Chemical …, 2020 - ACS Publications
The indolizidine alkaloid swainsonine (SW) is a deadly mycotoxin to livestock that can be
produced by different plant-associated fungi, including the endophytic entomopathogenic …

Inhibitory activities of indolizine derivatives: a patent review

KM Dawood, AA Abbas - Expert Opinion on Therapeutic Patents, 2020 - Taylor & Francis
Introduction Indolizines are structural isomers with indoles. Although several indole-based
commercial drugs are available in the market, none of the indolizine-based drugs are …

An overview of compounds derived from the shikimate and phenylpropanoid pathways and their medicinal importance

T Tohge, AR Fernie - Mini reviews in medicinal chemistry, 2017 - ingentaconnect.com
Objective: There has been a massive increase in the number of reports about the medicinal
benefits of the consumption of phenylpropanoids derived from the plastidic shikimate …

CRISPR/Cas9-mediated disruption of the PYRROLIDINE KETIDE SYNTHASE gene reduces the accumulation of tropane alkaloids in Atropa belladonna hairy roots

F Hasebe, H Yuba, T Hashimoto, K Saito… - Bioscience …, 2021 - academic.oup.com
Tropane alkaloids, including clinically important hyoscyamine and scopolamine, are
produced in the roots of medicinal plant species, such as Atropa belladonna, from the …

The biological activities of quinolizidine alkaloids

J Zhang, YQ Liu, J Fang - The Alkaloids: Chemistry and Biology, 2023 - Elsevier
Quinolizidine alkaloids isolated from various marine and terrestrial animals and plants are
primarily composed of lupinine-, matrine-, and sparteine-type alkaloids. Matrine …