MR-guidance in clinical reality: current treatment challenges and future perspectives

S Corradini, F Alongi, N Andratschke, C Belka… - Radiation …, 2019 - Springer
Abstract Magnetic Resonance-guided radiotherapy (MRgRT) marks the beginning of a new
era. MR is a versatile and suitable imaging modality for radiotherapy, as it enables direct …

Targeting hypoxia in solid and haematological malignancies

B Harris, S Saleem, N Cook, E Searle - Journal of Experimental & Clinical …, 2022 - Springer
Tumour hypoxia is a known and extensively researched phenomenon that occurs in both
solid and haematological malignancies. As cancer cells proliferate, demand for oxygen can …

The value of advanced MRI techniques in the assessment of cervical cancer: a review

E Dappa, T Elger, A Hasenburg, C Düber… - Insights into …, 2017 - Springer
Objectives To assess the value of new magnetic resonance imaging (MRI) techniques in
cervical cancer. Methods We searched PubMed and MEDLINE and reviewed articles …

Lattice or oxygen-guided radiotherapy: what if they converge? Possible future directions in the era of immunotherapy

G Ferini, V Valenti, A Tripoli, SI Illari, L Molino, S Parisi… - Cancers, 2021 - mdpi.com
Simple Summary Oxygen-guided radiotherapy is a new modality for cancer irradiation.
Spatially Fractionated Radiation Therapy allows the treatment of hypoxic tumor areas with …

Clinical imaging of hypoxia: Current status and future directions

P Bonnitcha, S Grieve, G Figtree - Free Radical Biology and Medicine, 2018 - Elsevier
Tissue hypoxia is a key feature of many important causes of morbidity and mortality. In
pathologies such as stroke, peripheral vascular disease and ischaemic heart disease …

Hypoxia in cervical cancer: from biology to imaging

H Lyng, E Malinen - Clinical and translational imaging, 2017 - Springer
Purpose Hypoxia imaging may improve identification of cervical cancer patients at risk of
treatment failure and be utilized in treatment planning and monitoring, but its clinical …

Daily AI-Based Treatment Adaptation under Weekly Offline MR Guidance in Chemoradiotherapy for Cervical Cancer 1: The AIM-C1 Trial

F Weykamp, E Meixner, N Arians… - Journal of Clinical …, 2024 - mdpi.com
(1) Background: External beam radiotherapy (EBRT) and concurrent chemotherapy,
followed by brachytherapy (BT), offer a standard of care for patients with locally advanced …

Hypoxia-targeted dose painting in radiotherapy

A Salem - Seminars in Radiation Oncology, 2023 - Elsevier
Hypoxia (oxygen deprivation) occurs in most solid malignancies, albeit with considerable
heterogeneity. Hypoxia is associated with an aggressive cancer phenotype by promotion of …

Functional imaging of hypoxia: PET and MRI

RC Perez, DH Kim, AWP Maxwell, JC Camacho - Cancers, 2023 - mdpi.com
Simple Summary The association between hypoxia, cancer aggressiveness and decreased
therapeutic response is well-established. With a significant body of evidence suggesting that …

The continuing evolution of molecular functional imaging in clinical oncology: the road to precision medicine and radiogenomics (Part I)

T Vaidya, A Agrawal, S Mahajan, MH Thakur… - Molecular diagnosis & …, 2019 - Springer
The present era of precision medicine sees 'cancer'as a consequence of molecular
derangements occurring at the commencement of the disease process, with morphologic …