Cancer is a major threat to the lives and health of people around the world, and the
development of effective antitumor drugs that exhibit fewer toxic effects is an important …

Ovarian cancer (OC) is gynecological cancer, and diagnosis and treatment are continuously
advancing. Next-generation sequencing (NGS)-based diagnoses have emerged as novel …

Aims The overexpression of ABC transporters on cancer cell membranes is one of the most
common causes of multidrug resistance (MDR). This study investigates the impact of ABCC1 …

Pentagalloyl glucose (PGG) is a natural hydrolyzable gallotannin abundant in various plants
and herbs. It has a broad range of biological activities, specifically anticancer activities, and …

PARP was an enzyme found in the nucleus of eukaryotic cells that played a crucial role in
repairing damaged DNA. Recently, PARP inhibitors have demonstrated great potential in …

Introduction PARP inhibitors block the DNA-repairing mechanism of PARP and represent a
promising class of anti-cancer therapy. The last decade has witnessed FDA approvals of …

The PARP1 protein plays a key role in DNA damage repair and ADP-ribosylation to regulate
gene expression. Strategies to target PARP1 have rapidly been developed for cancer …

Abstract Poly (ADP-ribose) polymerase (PARP) is considered an essential component in
case of DNA (Deoxyribonucleic acid) damage, response by sensing DNA damage and …

Intraperitoneal dissemination is the main method of epithelial ovarian cancer (EOC)
metastasis, which is related to poor prognosis and a high recurrence rate. Circular RNAs …

Purpose Cervical cancer is a common gynecological malignancy, pathologically associated
with persistent infection of high-risk types of human papillomavirus (HPV). Previous studies …