[HTML][HTML] Pathogenesis of osteoarthritis: risk factors, regulatory pathways in chondrocytes, and experimental models

Y He, Z Li, PG Alexander, BD Ocasio-Nieves, L Yocum… - Biology, 2020 - mdpi.com
As the most common chronic degenerative joint disease, osteoarthritis (OA) is the leading
cause of pain and physical disability, affecting millions of people worldwide. Mainly …

[HTML][HTML] An evidence-based systematic review of human knee post-traumatic osteoarthritis (PTOA): timeline of clinical presentation and disease markers, comparison …

CM Khella, R Asgarian, JM Horvath, B Rolauffs… - International Journal of …, 2021 - mdpi.com
Understanding the causality of the post-traumatic osteoarthritis (PTOA) disease process of
the knee joint is important for diagnosing early disease and developing new and effective …

Post‐traumatic osteoarthritis of the ankle: a distinct clinical entity requiring new research approaches

ML Delco, JG Kennedy, LJ Bonassar… - Journal of Orthopaedic …, 2017 - Wiley Online Library
The diagnosis of ankle osteoarthritis (OA) is increasing as a result of advancements in non‐
invasive imaging modalities such as magnetic resonance imaging, improved arthroscopic …

[HTML][HTML] Osteoarthritis: a narrative review of molecular approaches to disease management

LA Salman, G Ahmed, SG Dakin, B Kendrick… - Arthritis Research & …, 2023 - Springer
Osteoarthritis (OA) is a chronic, progressive degenerative whole joint disease that affects the
articular cartilage, subchondral bone, ligaments, capsule, and synovium. While it is still …

Targeting mitochondrial responses to intra-articular fracture to prevent posttraumatic osteoarthritis

MC Coleman, JE Goetz, MJ Brouillette, D Seol… - Science translational …, 2018 - science.org
We tested whether inhibiting mechanically responsive articular chondrocyte mitochondria
after severe traumatic injury and preventing oxidative damage represent a viable paradigm …

Changes in cytokines and aggrecan ARGS neoepitope in synovial fluid and serum and in C‐terminal crosslinking telopeptide of type II collagen and N‐terminal …

A Struglics, S Larsson, N Kumahashi… - Arthritis & …, 2015 - Wiley Online Library
Objective To prospectively monitor levels of proinflammatory cytokines and aggrecan ARGS
neoepitope in synovial fluid and serum as well as levels of C‐terminal crosslinking …

Autologous bone marrow concentrate: review and application of a novel intra-articular orthobiologic for cartilage disease

S Sampson, AB Bemden, D Aufiero - The Physician and …, 2013 - Taylor & Francis
Abstract Younger adults, aged< 65 years, increasingly present to their physicians with
advanced cartilage disease or post-traumatic osteoarthritis. A number of treatments exist for …

[HTML][HTML] Pathomechanisms of posttraumatic osteoarthritis: chondrocyte behavior and fate in a precarious environment

J Riegger, RE Brenner - International journal of molecular sciences, 2020 - mdpi.com
Traumatic injuries of the knee joint result in a wide variety of pathomechanisms, which
contribute to the development of so-called posttraumatic osteoarthritis (PTOA). These …

[HTML][HTML] Protoplast Isolation and Shoot Regeneration from Protoplast-Derived Callus of Petunia hybrida Cv. Mirage Rose

HH Kang, AH Naing, CK Kim - Biology, 2020 - mdpi.com
Despite the increasing use of protoplasts in plant biotechnology research, shoot
regeneration from protoplasts remains challenging. In this study, we investigated the factors …

Mitochondrial dysfunction is an acute response of articular chondrocytes to mechanical injury

ML Delco, ED Bonnevie, LJ Bonassar… - Journal of Orthopaedic …, 2018 - Wiley Online Library
Mitochondrial (MT) dysfunction is known to occur in chondrocytes isolated from end‐stage
osteoarthritis (OA) patients, but the role of MT dysfunction in the initiation and early …