The cells of the immune system respond to their environment through an array of signaling
receptors. Key among these, are the family of multichain immune recognition receptors …

Crosslinking of IgE bound FcεRI on mast cells and basophils by multivalent antigen leads to
degranulation and the release of key inflammatory mediators that stimulate the allergic …

Upon recognizing cognate antigen, B cells mobilize multiple cellular apparatuses to
propagate an optimal response. Antigen binding is transduced into cytoplasmic signaling …

Vaccines targeting the amyloid-β (Aβ) peptide have promise as immunotherapies for the
treatment of Alzheimer disease (AD). Human trials of a first generation Aβ vaccine …

Antigen binding to B-cell antigen receptors (BCRs) followed by signaling initiates the
humoral immune response. The signaling is intimately coupled to nanoclustering of BCRs …

Many autoimmune diseases are characterized by B cells that mistakenly recognize
autoantigens and produce antibodies toward self-proteins. Current therapies aim to …

B lymphocytes play a critical role in adaptive immunity. On antigen binding, B cell receptors
(BCR) cluster on the plasma membrane and are internalized by endocytosis. In this process …

Antigen (Ag)-triggered B-cell receptor (BCR) signaling initiates antibody responses.
However, prolonged or uncontrolled BCR signaling is associated with the development of …

Cells rapidly repair plasma membrane (PM) damage by a process requiring Ca2+-
dependent lysosome exocytosis. Acid sphingomyelinase (ASM) released from lysosomes …

For successful carbohydrate based anti-cancer vaccines, it is critical that B cells are
activated to secret antibodies targeting the tumor associated carbohydrate antigens …