Hallmarks of T cell aging
M Mittelbrunn, G Kroemer - Nature immunology, 2021 - nature.com
The aged adaptive immune system is characterized by progressive dysfunction as well as
increased autoimmunity. This decline is responsible for elevated susceptibility to infection …
increased autoimmunity. This decline is responsible for elevated susceptibility to infection …
T cell immunosenescence in aging, obesity, and cardiovascular disease
K Shirakawa, M Sano - Cells, 2021 - mdpi.com
Although advances in preventive medicine have greatly improved prognosis, cardiovascular
disease (CVD) remains the leading cause of death worldwide. This clearly indicates that …
disease (CVD) remains the leading cause of death worldwide. This clearly indicates that …
Impaired CD4+ T cell response in older adults is associated with reduced immunogenicity and reactogenicity of mRNA COVID-19 vaccination
N Jo, Y Hidaka, O Kikuchi, M Fukahori, T Sawada… - Nature Aging, 2023 - nature.com
Whether age-associated defects in T cells impact the immunogenicity and reactogenicity of
mRNA vaccines remains unclear. Using a vaccinated cohort (n= 216), we demonstrated that …
mRNA vaccines remains unclear. Using a vaccinated cohort (n= 216), we demonstrated that …
Extremely differentiated T cell subsets contribute to tissue deterioration during aging
G Soto-Heredero… - Annual Review of …, 2023 - annualreviews.org
There is a dramatic remodeling of the T cell compartment during aging. The most notorious
changes are the reduction of the naive T cell pool and the accumulation of memory-like T …
changes are the reduction of the naive T cell pool and the accumulation of memory-like T …
Critical role of the CD44lowCD62Llow CD8+ T cell subset in restoring antitumor immunity in aged mice
Y Nakajima, K Chamoto, T Oura… - Proceedings of the …, 2021 - National Acad Sciences
CD8+ T cells play a central role in antitumor immune responses that kill cancer cells directly.
In aged individuals, CD8+ T cell immunity is strongly suppressed, which is associated with …
In aged individuals, CD8+ T cell immunity is strongly suppressed, which is associated with …
Enhancing chimeric antigen receptor T cell therapy by modulating the p53 signaling network with Δ133p53α
C Roselle, I Horikawa, L Chen… - Proceedings of the …, 2024 - National Acad Sciences
Chimeric antigen receptor (CAR) T cell dysfunction is a major barrier to achieving lasting
remission in hematologic cancers, especially in chronic lymphocytic leukemia (CLL). We …
remission in hematologic cancers, especially in chronic lymphocytic leukemia (CLL). We …
CRISPR/Cas9: A powerful strategy to improve CAR-T cell persistence
W Wei, ZN Chen, K Wang - International Journal of Molecular Sciences, 2023 - mdpi.com
As an emerging treatment strategy for malignant tumors, chimeric antigen receptor T (CAR-
T) cell therapy has been widely used in clinical practice, and its efficacy has been markedly …
T) cell therapy has been widely used in clinical practice, and its efficacy has been markedly …
Aging and options to halt declining immunity to virus infections
MÁ Palacios-Pedrero, ADME Osterhaus… - Frontiers in …, 2021 - frontiersin.org
Immunosenescence is a process associated with aging that leads to dysregulation of cells of
innate and adaptive immunity, which may become dysfunctional. Consequently, older adults …
innate and adaptive immunity, which may become dysfunctional. Consequently, older adults …
Immunosenescence of T cells: a key player in rheumatoid arthritis
Y Gao, W Cai, Y Zhou, Y Li, J Cheng, F Wei - Inflammation Research, 2022 - Springer
Introduction The incidence of rheumatoid arthritis (RA) and its complications are expected to
increase with age. Remarkably, RA patients were identified features of accelerated aging …
increase with age. Remarkably, RA patients were identified features of accelerated aging …
Faster cytotoxicity with age: Increased perforin and granzyme levels in cytotoxic CD8+ T cells boost cancer cell elimination
D Zöphel, A Angenendt, L Kaschek… - Aging …, 2022 - Wiley Online Library
A variety of intrinsic and extrinsic factors contribute to the altered efficiency of CTLs in elderly
organisms. In particular, the efficacy of antiviral CD8+ T cells responses in the elderly has …
organisms. In particular, the efficacy of antiviral CD8+ T cells responses in the elderly has …