Ferroptosis: Emerging role in diseases and potential implication of bioactive compounds

GT Patanè, S Putaggio, E Tellone, D Barreca… - International Journal of …, 2023 - mdpi.com
Ferroptosis is a form of cell death that is distinguished from other types of death for its
peculiar characteristics of death regulated by iron accumulation, increase in ROS, and lipid …

Phenomics and robust multiomics data for cardiovascular disease subtyping

E Maiorino, J Loscalzo - Arteriosclerosis, Thrombosis, and …, 2023 - Am Heart Assoc
The complex landscape of cardiovascular diseases encompasses a wide range of related
pathologies arising from diverse molecular mechanisms and exhibiting heterogeneous …

Iron overload‐induced ferroptosis of osteoblasts inhibits osteogenesis and promotes osteoporosis: An in vitro and in vivo study

Z Jiang, H Wang, G Qi, C Jiang, K Chen, Z Yan - IUBMB life, 2022 - Wiley Online Library
Growing evidence indicates that iron overload is an independent risk factor for osteoporosis.
However, the mechanisms are not fully understood. The purpose of our study was to …

Suppression of lncRNA Gm47283 attenuates myocardial infarction via miR-706/ Ptgs2/ferroptosis axis

F Gao, Y Zhao, B Zhang, C Xiao, Z Sun, Y Gao… - …, 2022 - Taylor & Francis
Myocardial infarction (MI) is the leading cause of sudden death. Long non-doing RNAs
(lncRNAs) were demonstrated to play crucial roles in multiple diseases, including cancer …

Exploring the Communal Pathogenesis, Ferroptosis Mechanism, and Potential Therapeutic Targets of Dilated Cardiomyopathy and Hypertrophic Cardiomyopathy via …

Z Wang, Q Xia, W Su, M Cao, Y Sun… - Frontiers in …, 2022 - frontiersin.org
Background Cardiomyopathies are a heterogeneous group of heart diseases that can
gradually cause severe heart failure. In particular, dilated cardiomyopathy (DCM) and …

Curdione inhibits ferroptosis in isoprenaline‐induced myocardial infarction via regulating Keap1/Trx1/GPX4 signaling pathway

H Wang, B Xie, S Shi, R Zhang, Q Liang… - Phytotherapy …, 2023 - Wiley Online Library
Myocardial infarction (MI) is a common disease with high morbidity and mortality. Curdione
is a sesquiterpenoid from Radix Curcumae. The current study is aimed to investigate the …

Potential intervention target of atherosclerosis: Ferroptosis

J Li, L Xu, YX Zuo, XQ Chang… - Molecular Medicine …, 2022 - spandidos-publications.com
Atherosclerosis (AS) is a chronic inflammatory disease of the blood vessels, which is mainly
characterized by the form of atherosclerotic plaques and vascular endothelial injury. Its …

NMDARs activation regulates endothelial ferroptosis via the PP2A-AMPK-HMGB1 axis

WM Han, YX Hong, GS Xiao, RY Wang, G Li - Cell Death Discovery, 2024 - nature.com
N-methyl-D-aspartate receptors (NMDARs) are ligand-gated, voltage-dependent channels
of the ionotropic glutamate receptor family. The present study explored whether NMDAR …

[HTML][HTML] Ferroptosis in cardiovascular disease

G Liu, X Xie, W Liao, S Chen, R Zhong, J Qin… - Biomedicine & …, 2024 - Elsevier
In the 21st century, cardiovascular disease (CVD) has become one of the leading causes of
death worldwide. The prevention and treatment of CVD remain pressing scientific issues …

Ferrostatin-1 suppresses cardiomyocyte ferroptosis after myocardial infarction by activating Nrf2 signaling

YT Wu, GY Zhang, Y Hua, HJ Fan, X Han… - Journal of Pharmacy …, 2023 - academic.oup.com
Objectives Ferroptosis, a new regulated cell death pathway, plays a crucial part in the
development of cardiovascular disease. However, the precise underlying mechanism …