The remarkable T cell receptor (TCR) performs essential functions in the initiation of
intracellular signals required for T cell development, repertoire selection and effector …

From HIV to influenza, the battle between infectious agents and the immune system is at the
heart of disease. Knowledge of how and why parasites vary to escape recognition by the …

The structurally related T cell surface molecules CD28 and CTLA-4 interact with cell surface
ligands CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells (APC) and modulate T …

Dendritic cells (DCs) are bone marrow-derived cells of both lymphoid and myeloid stem cell
origin that populate all lymphoid organs including the thymus, spleen, and lymph nodes, as …

Functional discrimination between structurally similar self and foreign antigens is a main
attribute of adaptive immunity. Here we describe two feedback mechanisms in T …

Protection against pathogens is a prerequisite for survival of most organisms. To cope with
this continuous challenge, complex defense mechanisms have evolved. The construction …

The T cell receptor (TCR) inherently has dual specificity. T cells must recognize self-antigens
in the thymus during maturation and then discriminate between foreign pathogens in the …

CD5 is a transmembrane protein that is expressed on the surface of T cells and a subset of B
cells. The absence of CD5 rendered thymocytes hyperresponsive to stimulation through the …

In the absence of thymic emigration, the peripheral T cell pool is maintained by division of
mature lymphocytes. We have examined the molecular interactions required for peripheral …

The elucidation of the phenomena of T cell antagonism and partial activation by altered
peptide ligands has necessitated a revision in the traditional concepts of TCR recognition of …