CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond

AF Russo, DL Hay - Physiological reviews, 2023 - journals.physiology.org
Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …

The glymphatic system: a novel component of fundamental neurobiology

LM Hablitz, M Nedergaard - Journal of Neuroscience, 2021 - Soc Neuroscience
Throughout the body, lymphatic fluid movement supports critical functions including
clearance of excess fluid and metabolic waste. The glymphatic system is the analog of the …

[HTML][HTML] The emergence and influence of internal states

SW Flavell, N Gogolla, M Lovett-Barron, M Zelikowsky - Neuron, 2022 - cell.com
Animal behavior is shaped by a variety of" internal states"—partially hidden variables that
profoundly shape perception, cognition, and action. The neural basis of internal states, such …

The oxytocin receptor: from intracellular signaling to behavior

B Jurek, ID Neumann - Physiological reviews, 2018 - journals.physiology.org
The many facets of the oxytocin (OXT) system of the brain and periphery elicited nearly
25,000 publications since 1930 (see, as listed in PubMed), which revealed central roles for …

A genetically encoded sensor measures temporal oxytocin release from different neuronal compartments

T Qian, H Wang, P Wang, L Geng, L Mei… - Nature …, 2023 - nature.com
Oxytocin (OT), a peptide hormone and neuromodulator, is involved in diverse physiological
and pathophysiological processes in the central nervous system and the periphery …

[HTML][HTML] Maternal plasma levels of oxytocin during physiological childbirth–a systematic review with implications for uterine contractions and central actions of oxytocin

K Uvnäs-Moberg, A Ekström-Bergström, M Berg… - BMC pregnancy and …, 2019 - Springer
Background Oxytocin is a key hormone in childbirth, and synthetic oxytocin is widely
administered to induce or speed labour. Due to lack of synthetized knowledge, we …

The neurobiology of human attachments

R Feldman - Trends in cognitive sciences, 2017 - cell.com
Attachment bonds are a defining feature of mammals. A conceptual framework on human
attachments is presented, integrating insights from animal research with neuroimaging …

Oxytocin, vasopressin, and social behavior: from neural circuits to clinical opportunities

N Rigney, GJ de Vries, A Petrulis, LJ Young - Endocrinology, 2022 - academic.oup.com
Oxytocin and vasopressin are peptide hormones secreted from the pituitary that are well
known for their peripheral endocrine effects on childbirth/nursing and blood pressure/urine …

[HTML][HTML] Single-cell RNA-seq reveals hypothalamic cell diversity

R Chen, X Wu, L Jiang, Y Zhang - Cell reports, 2017 - cell.com
The hypothalamus is one of the most complex brain structures involved in homeostatic
regulation. Defining cell composition and identifying cell-type-specific transcriptional …

[HTML][HTML] Social touch-like tactile stimulation activates a tachykinin 1-oxytocin pathway to promote social interactions

H Yu, W Miao, E Ji, S Huang, S Jin, X Zhu, MZ Liu… - Neuron, 2022 - cell.com
It is well known that affective and pleasant touch promotes individual well-being and
facilitates affiliative social communication, although the neural circuit that mediates this …