Rheumatoid arthritis (RA) is a common autoimmune disease with unknown etiology and
pathogenesis. Although major therapeutic advances have been made in recent years, there …

Dysregulated autoantibodies and cytokines were deemed to provide important cues for
potential illnesses, such as various carcinomas and autoimmune diseases. Increasing …

Background & Aims Rheumatoid arthritis (RA) is a prototypic autoimmune disease causing
inflammatory polyarthritis that affects nearly 1% of the population. RA can lead to joint …

IBDs, encompassing Crohn's disease (CD) and UC, are chronic, relapsing and remitting,
inflammatory diseases of the GI tract. IBD is emerging as a globally important disease with …

Highlights•RA exhibits a long preclinical period with autoantibodies and other
biomarkers.•Highly specific preclinical autoimmunity to citrullinated antigens develops …

Chemokines and cytokines are key signaling molecules that orchestrate the trafficking of
immune cells, direct them to sites of tissue injury and inflammation and modulate their states …

A unique feature of rheumatoid arthritis (RA) is the presence of anti-citrullinated protein
antibodies (ACPA). Several risk factors for RA are known to increase the expression or …

Objective Systemic lupus erythematosus (SLE) and other autoimmune diseases cause
significant morbidity. Identifying populations at risk of developing SLE is essential for …

Summary Interleukin (IL)-9 is a 28-30 kDa monomeric glycosylated polypeptide belonging to
the IL-7/IL-9 family of proteins that bind to a composite receptor consisting of the private …

The development of RA is conceived as a multiple hit process and the more hits that are
acquired, the greater the risk of developing clinically apparent RA. Several at-risk phases …