Subjects at-risk for future development of rheumatoid arthritis demonstrate a PAD4-and TLR-dependent enhanced histone H3 citrullination and proinflammatory …

Y Okamato, T Ghosh, T Okamoto, RP Schuyler… - Journal of …, 2021 - Elsevier
The presence of anti-citrullinated protein/peptide antibodies (ACPA) and epitope spreading
across the target autoantigens is a unique feature of rheumatoid arthritis (RA). ACPA are …

Pathways of impending disease flare in African-American systemic lupus erythematosus patients

ME Munroe, ES Vista, JT Merrill, JM Guthridge… - Journal of …, 2017 - Elsevier
Immune dysregulation in systemic lupus erythematosus (SLE) contributes to increased
disease activity. African-American (AA) SLE patients have an increased prevalence of …

ACPA and bone loss in rheumatoid arthritis

R Kocijan, U Harre, G Schett - Current rheumatology reports, 2013 - Springer
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease characterized by bone
loss. Degree of inflammation and autoantibody positivity have both been identified as …

Recent advances in defining the genetic basis of rheumatoid arthritis

C Terao, S Raychaudhuri… - Annual review of …, 2016 - annualreviews.org
Rheumatoid arthritis (RA) is the most common inflammatory arthritis and exhibits genetic
overlap with other autoimmune and inflammatory disorders. Although predominant …

Autoimmunity in rheumatoid arthritis: citrulline immunity and beyond

L Klareskog, K Lundberg, V Malmström - Advances in immunology, 2013 - Elsevier
Rheumatoid arthritis (RA) represents a disease where we have recently acquired new
knowledge on etiology and molecular pathogenesis, by combining data from studies on …

[HTML][HTML] Identification of a potential proinflammatory genetic profile influencing carotid plaque vulnerability

F Biscetti, G Straface, G Bertoletti, C Vincenzoni… - Journal of Vascular …, 2015 - Elsevier
Objective Atherosclerosis and vascular remodeling after injury are driven by inflammation
and mononuclear cell infiltration. Unstable atherosclerotic plaques are characterized by a …

Immunosensors for biomarker detection in autoimmune diseases

X Zhang, A Zambrano, ZT Lin, Y Xing, J Rippy… - Archivum Immunologiae …, 2017 - Springer
Autoimmune diseases occur when the immune system generates proinflammatory
molecules and autoantibodies that mistakenly attack their own body. Traditional diagnosis of …

[HTML][HTML] Systemic interleukin-9 in inflammatory bowel disease: Association with mucosal healing in ulcerative colitis

M Matusiewicz, K Neubauer… - World Journal of …, 2017 - ncbi.nlm.nih.gov
AIM To evaluate circulating IL9 in inflammatory bowel disease and disease-associated
anemia/cachexia and assess its potential as a mucosal healing marker. METHODS Serum …

Association of rheumatoid factors with subclinical and clinical atherosclerosis in African American women: the multiethnic study of atherosclerosis

DS Majka, THT Vu, RM Pope… - Arthritis Care & …, 2017 - Wiley Online Library
Objective Although the association between rheumatoid arthritis (RA) and cardiovascular
disease (CVD) is established, the exact mechanism is unknown. We tested the hypothesis …

Association of Lipid Mediators With Development of Future Incident Inflammatory Arthritis in an Anti–Citrullinated Protein Antibody–Positive Population

KJ Polinski, EA Bemis, F Yang, T Crume… - Arthritis & …, 2021 - Wiley Online Library
Objective To determine the association of polyunsaturated fatty acid (PUFA)–derived lipid
mediators with progression from rheumatoid arthritis (RA)–related autoimmunity to …