Atherosclerosis is the main underlying pathology for many cardiovascular diseases (CVDs),
which are the leading cause of death globally and represent a serious health crisis …

The heart requires fatty acids to maintain its activity. Various mechanisms regulate
myocardial fatty acid metabolism, such as energy production using fatty acids as fuel, for …

Statins, which are widely used to treat hypercholesterolemia, have anti-inflammatory and
anti-oxidant effects. These are thought to be responsible for the potential effects of statins on …

Hypercholesterolaemia is considered to be a principle risk factor for cardiovascular disease,
having direct negative effects on the myocardium itself, in addition to the development of …

Statins, a class of drugs that act as inhibitors of cholesterol biosynthesis and protein
isoprenylation, have been proposed as immunomodulatory agents due to their potent effects …

Statins are widely used in the treatment of dyslipidemia and associated cardiovascular
abnormalities including atherosclerosis, hypertension and coronary heart disease. Needless …

Myocardial infarction (MI) continues to be a major public health problem in the world. Statins
exhibit cardio-protective effects by several mechanisms beyond their lipid lowering activity …

Simvastatin (SIM) is a lipid-soluble inhibitor of hydroxy-3-methylglutaryl coenzyme A
reductase with multiple reported therapeutic benefits. The present study was designed to …

Described since long as a member of the nuclear receptor superfamily, peroxisome
proliferator-activated receptors (PPARs) regulate the gene expression of proteins involved in …

Objective: This study aimed to evaluate the protective effects of atorvastatin against
myocardial ischemia/reperfusion (I/R) injury in cardiomyocytes and its possible underlying …