Survival improves when cancer is detected early. However,~ 50% of cancers are at an
advanced stage when diagnosed. Early detection of cancer or precancerous change allows …

The traditional view of chronic obstructive pulmonary disease (COPD) as a self-inflicted
disease caused by tobacco smoking in genetically susceptible individuals has been …

Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …

Epigenetics is closely related to cardiovascular diseases. Genome-wide linkage and
association analyses and candidate gene approaches illustrate the multigenic complexity of …

Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These
inputs—which include both nutrient availability as a result of diet and growth factor signalling …

Epigenetic research has accelerated rapidly in the twenty-first century, generating justified
excitement and hope, but also a degree of hype. Here we review how the field has evolved …

With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …

The incidence of early-onset colorectal cancer (CRC), which occurs in individuals< 50 years
of age, has been increasing worldwide and particularly in high-income countries. The …

In contrast to the decreasing incidence of colorectal cancer (CRC) in older populations, the
incidence has nearly doubled in younger adults since the early 1990s. Approximately 1 in …

Although health disparities in women presenting with acute coronary syndrome (ACS) have
received growing attention in recent years, clinical outcomes from ACS are still worse for …