Chewing the fat: How lipidomics is changing our understanding of human health and disease in 2022

C Géhin, SJ Fowler, DK Trivedi - Analytical Science Advances, 2023 - Wiley Online Library
Lipids are biological molecules that play vital roles in all living organisms. They perform
many cellular functions, such as 1) forming cellular and subcellular membranes, 2) storing …

Proteomic approaches to study ubiquitinomics

I Sahu, H Zhu, SJ Buhrlage, JA Marto - Biochimica et Biophysica Acta (BBA) …, 2023 - Elsevier
As originally described some 40 years ago, protein ubiquitination was thought to serve
primarily as a static mark for protein degradation. In the ensuing years, it has become clear …

Optimization of mass spectrometric parameters in data dependent acquisition for untargeted metabolomics on the basis of putative assignments

HA Assress, MG Ferruzzi, RS Lan - Journal of the American …, 2023 - ACS Publications
Optimization of mass spectrometric parameters for a data dependent acquisition (DDA)
experiment is essential to increase the MS/MS coverage and hence increase metabolite …

Exploring Human Metabolome after Wine Intake—A Review

P Lekka, E Fragopoulou, A Terpou, M Dasenaki - Molecules, 2023 - mdpi.com
Wine has a rich history dating back to 2200 BC, originally recognized for its medicinal
properties. Today, with the aid of advanced technologies like metabolomics and …

Clinical metabolomics characteristics of diabetic kidney disease: A meta‐analysis of 1875 cases with diabetic kidney disease and 4503 controls

Y Yuan, L Huang, L Yu, X Yan, S Chen… - Diabetes/Metabolism …, 2024 - Wiley Online Library
Abstract Aims Diabetic Kidney Disease (DKD), one of the major complications of diabetes, is
also a major cause of end‐stage renal disease. Metabolomics can provide a unique …

Scaling-up metabolomics: Current state and perspectives

G Hajjar, MCB Santos, J Bertrand-Michel… - TrAC Trends in …, 2023 - Elsevier
Metabolomics is now a mature phenotyping tool that provides substantial results within
various scientific communities. Its application at large-scale, ie on large populations and/or …

Feature-Based Molecular Networking Combined with Multivariate Analysis for the Characterization of Glutathione Adducts as a Smoking Gun of Bioactivation

YH Jung, JH Kim - Analytical Chemistry, 2023 - ACS Publications
Feature-based molecular networking (FBMN) is a powerful analytical tool for mass
spectrometry (MS)-based untargeted metabolomics data analysis. FBMN plays an important …

[HTML][HTML] Integration of a hybrid scan approach and in-house high-resolution MS2 spectral database for charactering the multicomponents of Xuebijing Injection

W Hu, X Xu, Y Qian, F Yang, H Wang, B Chen… - Arabian Journal of …, 2023 - Elsevier
Xuebijing (XBJ) Injection is a reputable patent Chinese medicine widely used to cure sepsis,
among the Chinese ″Three Medicines and Three Prescriptions ″solution to fight against …

Recent Analytical Methodologies in Lipid Analysis

I Gerhardtova, T Jankech, P Majerova… - International Journal of …, 2024 - mdpi.com
Lipids represent a large group of biomolecules that are responsible for various functions in
organisms. Diseases such as diabetes, chronic inflammation, neurological disorders, or …

[HTML][HTML] Inferring early-life host and microbiome functions by mass spectrometry-based metaproteomics and metabolomics

VK Pettersen, LCM Antunes, A Dufour… - Computational and …, 2022 - Elsevier
Humans have a long-standing coexistence with microorganisms. In particular, the microbial
community that populates the human gastrointestinal tract has emerged as a critical player …