In silico evaluation of pharmacokinetics and acute toxicity of withanolides in Ashawagandha

Y Liu - Phytochemistry Letters, 2022 - Elsevier
Ashwagandha is a medicinal plant used in traditional Asian medicines as an adaptogen to
promote both physical and mental health. Withanolides are the major bioactive …

[HTML][HTML] Neuroprotective effect of Withania somnifera leaves extract nanoemulsion against penconazole-induced neurotoxicity in albino rats via modulating TGF-β1 …

M Abomosallam, BM Hendam, AA Abdallah… - …, 2024 - Springer
Penconazole (PEN) is a systemic triazole fungicide used to control various fungal diseases
on grapes, stone fruits, cucurbits, and strawberries. Still, it leaves residues on treated crops …

In Silico Prediction of Potential Inhibitors for Targeting RNA CAG Repeats via Molecular Docking and Dynamics Simulation: A Drug Discovery Approach

S Singh, S Singh, D Joshi, C Mohanty… - Journal of Cellular …, 2024 - Wiley Online Library
Spinocerebellar ataxia (SCA) is a rare neurological illness inherited dominantly that causes
severe impairment and premature mortality. While each rare disease may affect individuals …

Mitochondria Modulating Therapeutic Approaches in the Management of Huntington's Disease

A Sood, VK Garg, HS Tuli, A Chauhan… - Current Pharmacology …, 2024 - Springer
This review highlights the therapeutic potential of mitochondrial drug targeting and
limitations of currently available mitochondria-targeted drugs (synthetic and natural …

[HTML][HTML] Navigating neurological disorders: harnessing the power of natural compounds for innovative therapeutic breakthroughs

R Rushendran, RF Begum, A Singh, PL Narayanan… - EXCLI …, 2024 - ncbi.nlm.nih.gov
Novel treatments are needed as neurological issues become more frequent worldwide.
According to the report, plants, oceans, microorganisms, and animals contain interesting …

Role of Withania somnifera (Ashwagandha) in the treatment of neurological disorders

S Sharma - Current Nutrition & Food Science, 2023 - ingentaconnect.com
Different formulations of ashwagandha have been utilized for the treatment of neurological
disorders. The present manuscript aimed to discuss various roles of Withania somnifera …

A Review On Huntington Protein: Insight Into Protein Aggregation and Therapeutic Interventions

E Srinivasan, V Ram… - Current Drug …, 2022 - ingentaconnect.com
Huntington's disease (HD) is a distressing, innate neurodegenerative disease that descends
from CAG repeat expansion in the huntingtin gene causing behavioral changes, motor …

[HTML][HTML] Natural Medicines and Their Underlying Mechanisms of Prevention and Recovery from Amyloid Β-Induced Axonal Degeneration in Alzheimer's Disease

T Kuboyama, X Yang, C Tohda - International Journal of Molecular …, 2020 - mdpi.com
In Alzheimer's disease (AD), amyloid β (Aβ) induces axonal degeneration, neuronal network
disruption, and memory impairment. Although many candidate drugs to reduce Aβ have …

[PDF][PDF] Update on the preclinical and clinical assessment of Withania somnifera: from ancient Rasayana to modern perspectives

SR Akanksha, A Islam, R Arora, H Singh… - Tradit Med …, 2022 - researchgate.net
Abstract The Rasayana plant Withania somnifera (W. somnifera) Dunal, also known as
“Ashwagandha”, has been mentioned in various classical Ayurvedic texts, such as Charaka …

Effects of amitriptyline and ashwagandha on the oxidative state and acetylcholine esterase enzyme activities in rats

IR Idrees, GAA Taqa, SKA ALtaaye - Journal of Applied Veterinary …, 2023 - journals.ekb.eg
Amitriptyline has a long history of effectiveness in treating depression. Due to its side effects,
which include oxidative stress and anticholinergic effects, it is used less frequently …