Secretory epithelial cells of the proximal airways synthesize and secrete gel-forming
polymeric mucins. The secreted mucins adsorb water to form mucus that is propelled by …

Advancements in techniques for analysis of mucociliary clearance have improved our
understanding of the interaction between the respiratory epithelium and the airway surface …

Chronic airway diseases like cystic fibrosis, chronic bronchitis, asthma, diffuse
panbronchiolitis, and bronchiectasis are all associated with chronic inflammation. The …

The efficiency of the mucociliary clearance (MCC) process that removes noxious materials
from airway surfaces depends on the balance between mucin secretion, airway surface …

▪ Abstract Airways are embedded in the mechanically dynamic environment of the lung. In
utero, this mechanical environment is defined largely by fluid secretion into the developing …

Ca+-dependent Cl− channels (CaCCs) play a variety of physiological roles in different
organs and tissues, including transepithelial Cl− secretion, smooth muscle contraction …

Cystic fibrosis patients exhibit lung disease consistent with a failure of innate airway defense
mechanisms. The link between abnormal ion transport and disease initiation and …

Cystic fibrosis is caused by impaired ion transport due to mutated cystic fibrosis
transmembrane conductance regulator, accompanied by elevated activity of the amiloride …

Cough is among the most common complaints for which patients worldwide seek medical
attention. In a majority of patients with chronic cough (defined as cough of greater than 8 …

Chronic obstructive pulmonary disease (COPD) is one of the prevalent causes of worldwide
mortality and encompasses two major clinical phenotypes, ie, chronic bronchitis (CB) and …