Improved understanding of structure and function relationships in the human lungs in
individuals and subpopulations is fundamentally important to the future of pulmonary …

Background Despite the occurrence of the nasal cycle being well documented, the
functional purpose of this phenomenon is not well understood. This investigation seeks to …

Mucociliary clearance (MCC) is an important innate defense mechanism that continuously
removes inhaled pathogens and particulates from the airways. Normal MCC is essential for …

Airway dehydration causes mucus stasis and bacterial overgrowth in cystic fibrosis and
chronic bronchitis (CB). Rehydration by hypertonic saline is efficacious but suffers from a …

The cystic fibrosis transmembrane conductance regulator CFTR gene is found on
chromosome 7 [Kerem, B., Rommens, JM, Buchanan, JA, Markiewicz, D., Cox, TK …

In humans and mice, the first line of innate defense against inhaled pathogens and particles
in the respiratory tract is airway mucus. The primary solid components of the mucus layer are …

CFTR is an integral transmembrane glycoprotein and a cAMP-activated Cl− channel.
Mutations in the CFTR gene lead to Cystic Fibrosis (CF)–an autosomal recessive disease …

Cystic fibrosis transmembrane conductance regulator (CFTR)-mediated Cl-secretion across
fluid-transporting epithelia is regulated, in part, by modulating the number of CFTR Cl …

Airway mucin secretion studies have focused on goblet cell responses to exogenous
agonists almost to the exclusion of baseline mucin secretion (BLMS). In human bronchial …

Large conductance, Ca 2+-activated, and voltage-dependent K+(BK) channels control a
variety of physiological processes in nervous, muscular, and renal epithelial tissues. In …