Proteostasis (Balch WE, Morimoto RI, Dillin A, Kelly JW. Adapting proteostasis for disease
intervention. Science 2008; 319: 916–919) refers to the biology that maintains the proteome …

Background Mucus hyperconcentration in cystic fibrosis (CF) lung disease is marked by
increases in both mucin and DNA concentration. Additionally, it has been shown that half of …

Lung function is inextricably linked to mechanics. On short timescales every breath
generates dynamic cycles of cell and matrix stretch, along with convection of fluids in the …

Epithelial cells express calcium-activated Cl− channels of unknown molecular identity.
These Cl− channels play a central role in diseases such as secretory diarrhea, polycystic …

We discuss in detail techniques for modelling flows due to finite and infinite arrays of beating
cilia. An efficient technique, based on concepts from previous 'singularity models' is …

The ability to breathe air represents a fundamental step in vertebrate evolution that was
accompanied by several anatomical and physiological adaptations. The morphology of the …

In mucosal drug delivery, two design goals are desirable: 1) insure drug passage through
the mucosal barrier to the epithelium prior to drug removal from the respective organ via …

The mucociliary clearance system is comprised of three components, ion transport activities
controlling the height of airway surface liquid (ASL), mucin secretion, and ciliary activity …

Abstract The epithelial Na+ channel (ENaC) is the rate-limiting step for Na+ absorption in
various vertebrate epithelia and deeply enmeshed in the control of salt and water …

Exposure of lung airways to detrimental suspended aerosols in the environment increases
the vulnerability of the respiratory and cardiovascular systems. In addition, recent …