Molecular imaging and disease theranostics with renal-clearable optical agents

P Cheng, K Pu - Nature Reviews Materials, 2021 - nature.com
Optical imaging in disease diagnosis and treatment benefits from high spatiotemporal
resolution and the availability of numerous optical agents. However, many optical imaging …

Toxic metal implications on agricultural soils, plants, animals, aquatic life and human health

U Okereafor, M Makhatha, L Mekuto… - International journal of …, 2020 - mdpi.com
The problem of environmental pollution is a global concern as it affects the entire ecosystem.
There is a cyclic revolution of pollutants from industrial waste or anthropogenic sources into …

Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases

T Liu, B Xiao, F Xiang, J Tan, Z Chen, X Zhang… - Nature …, 2020 - nature.com
Oxidative stress is associated with many acute and chronic inflammatory diseases, yet
limited treatment is currently available clinically. The development of enzyme-mimicking …

Characterization of ferroptosis in kidney tubular cell death under diabetic conditions

S Kim, SW Kang, J Joo, SH Han, H Shin, BY Nam… - Cell Death & …, 2021 - nature.com
Kidney tubular cell death induced by transforming growth factor-β1 (TGF-β1) is known to
contribute to diabetic nephropathy, a major complication of diabetes. Caspase-3-dependent …

Molecular optical imaging probes for early diagnosis of drug-induced acute kidney injury

J Huang, J Li, Y Lyu, Q Miao, K Pu - Nature materials, 2019 - nature.com
Drug-induced acute kidney injury (AKI) with a high morbidity and mortality is poorly
diagnosed in hospitals and deficiently evaluated in drug discovery. Here, we report the …

Mitochondrial energetics in the kidney

P Bhargava, RG Schnellmann - Nature Reviews Nephrology, 2017 - nature.com
The kidney requires a large number of mitochondria to remove waste from the blood and
regulate fluid and electrolyte balance. Mitochondria provide the energy to drive these …

[HTML][HTML] Physiological factors characterizing heat-vulnerable older adults: a narrative review

RD Meade, AP Akerman, SR Notley, R McGinn… - Environment …, 2020 - Elsevier
More frequent and intense periods of extreme heat (heatwaves) represent the most direct
challenge to human health posed by climate change. Older adults are particularly …

[HTML][HTML] Comparison of machine learning and logistic regression models in predicting acute kidney injury: A systematic review and meta-analysis

X Song, X Liu, F Liu, C Wang - International journal of medical informatics, 2021 - Elsevier
Introduction We aimed to assess whether machine learning models are superior at
predicting acute kidney injury (AKI) compared to logistic regression (LR), a conventional …

[HTML][HTML] Acute kidney injury: definition, pathophysiology and clinical phenotypes

K Makris, L Spanou - The clinical biochemist reviews, 2016 - ncbi.nlm.nih.gov
Acute kidney injury (AKI) is a clinical syndrome that complicates the course and worsens the
outcome in a significant number of hospitalised patients. Recent advances in clinical and …

Heart failure and kidney dysfunction: epidemiology, mechanisms and management

JC Schefold, G Filippatos, G Hasenfuss… - Nature Reviews …, 2016 - nature.com
Heart failure (HF) is a major health-care problem and the prognosis of affected patients is
poor. HF often coexists with a number of comorbidities of which declining renal function is of …