The increasing importance of in vitro-transcribed (IVT) mRNA for synthesizing the encoded
therapeutic protein in vivo demands the manufacturing of pure mRNA products. The major …

Long non-coding RNAs (lncRNAs) are emerging as a major class of gene products that
have central roles in cell and developmental biology. Natural antisense transcripts (NATs) …

Natural antisense transcripts (NATs) are RNA molecules that originate from opposite DNA
strands of the same genomic locus (cis-NAT) or unlinked genomic loci (trans-NAT). NATs …

Next-generation RNA-sequencing (RNA-seq) has revolutionized transcriptome profiling,
gene expression analysis, and RNA-based diagnostics. Here, we developed a new RNA …

Induction of nucleic acid sensing–mediated type I interferon (IFN) has emerged as a novel
approach to activate the immune system against cancer. Here we show that the depletion of …

Background The cytoplasmic RIG-like receptors are responsible for the early detection of
viruses and other intracellular microbes by activating the innate immune response mediated …

Many human genes are transcribed from both strands and produce sense-antisense gene
pairs. Sense-antisense (SAS) chimeric transcripts are produced upon the coalescing of …

DNA damage has been considered the primary action of ionizing radiation (IR) in normal
and tumor cells resulting in cell autonomous death. However, recent findings have …

Various sensors that detect double-stranded RNA, presumably of viral origin, exist in
eukaryotic cells and induce IFN-responses. Ongoing IFN-responses have also been …

Most virus infections are controlled through the innate and adaptive immune system. A
surprisingly limited number of so-called pattern recognition receptors (PRRs) have the ability …