This chapter provides an updated review on anatomy and physiology of aqueous production
and outflow geared toward the clinician. The composition and flow pathways for aqueous …

Purpose.: In this study, we investigate how adenosine monophosphate–activated protein
kinase (AMPK) affects extracellular matrix (ECM) and cellular tone in the trabecular …

Purpose To determine whether there are identifiable, reproducible findings in the trabecular
meshwork (TM) of patients with primary open-angle glaucoma (POAG) who underwent …

Purpose: Secreted protein, acidic and rich in cysteine (SPARC) elevates intraocular
pressure (IOP), increases certain structural extracellular matrix (ECM) proteins in the …

The present study aimed to compare microbead injection with and without hydroxypropyl
methylcellulose (HPM) in order to establish an experimental animal model of glaucoma. This …

Background Elevated intraocular pressure (lOP) is primarily due to increased aqueous
outflow resistance, but how aqueous outflow resistance is generated and regulated are still …

Simple Summary Glaucoma disease shows a multifactorial pathogenesis, with increased
intraocular pressure being the main risk factor. As retinal microcirculation was observed to …

Purpose: To investigate the flow pattern in unconventional outflow and its correlation with
conventional outflow in mouse eyes. Methods: Fluorescent microspheres were injected into …

In the past decade, many new pharmacological and surgical treatments have become
available to lower intraocular pressure (IOP) for glaucoma. The majority of these options …

Endothelium phenotype is known to be closely associated with flow shear stress. This study
is to determine the topographic distribution of endothelial cells and the phenotype of …