Throughout the gastrointestinal (GI) tract, a distinct mucus layer composed of highly
glycosylated proteins called mucins plays an essential role in providing lubrication for the …

Mucus is a complex viscoelastic gel and acts as a barrier covering much of the soft tissue in
the human body. High vascularization and accessibility have motivated drug delivery to …

Abstract Background Tumor-associated macrophages (TAMs) are classified into two major
phenotypes, M1 and M2. M1 TAMs suppress cancer progression, while M2 TAMs promote it …

The toxic mechanisms of trichothecenes, including T-2 toxin and deoxynivalenol (DON), are
closely related with their effects on protein synthesis. Increasing lines of evidence show that …

In many different human disorders, the cellular glycome is altered. An interesting but poorly
understood alteration occurs in the mucin‐type O‐glycome, in which there is aberrant …

Technological advances in the large scale analysis of human genetics have generated
profound insights into possible genetic contributions to chronic diseases including the …

Colitis, an inflammatory bowel disease, is caused by a variety of factors, but luminal
microbiota are thought to play crucial roles in disease development and progression. Indole …

The gut barrier is a functional unit, organized as a multi-layer system, made up of two main
components: a physical barrier surface, which prevents bacterial adhesion and regulates …

Natural products of plant origin are of high interest and widely used, especially in the food
industry, due to their low toxicity and wide range of bioactive properties. Compared to other …

Protein glycosylation represents a nearly ubiquitous post-translational modification, and
altered glycosylation can result in clinically significant pathological consequences. Here we …