Exploring the prominent performance of CX-4945 derivatives as protein kinase CK2 inhibitors by a combined computational study
Protein kinase CK2, also known as casein kinase II, is related to various cellular events and
is a potential target for numerous cancers. In this study, we attempted to gain more insight …
is a potential target for numerous cancers. In this study, we attempted to gain more insight …
An efficient microwave assisted synthesis of N′-aryl/(alkyl)-substituted N-(4-hydroxy-6-phenylpyrimidin-2-yl) guanidines: Scope and limitations
PA Machicao, SR Burt, RK Christensen, NB Lohner… - Tetrahedron …, 2017 - Elsevier
Abstract Treatment of N-[(4-hydroxy-6-phenyl) pyrimidin-2-yl] cyanamide with 1° alkyl or
arylamines in isopropyl alcohol for only 10 min at 110–120° C under microwave conditions …
arylamines in isopropyl alcohol for only 10 min at 110–120° C under microwave conditions …
Synthesis and Biological Evaluation of Pyrazolo [1, 5-a] pyrimidines and (4-Hydroxy-6-trifluoromethylpyrimidin-2-yl) guanidines
JD Singleton - 2021 - search.proquest.com
A microwave reactor was used to synthesize a series of novel 3, 6-disubstituted or 3-
substituted pyrazolo [1, 5-a] pyrimidines in a total of 1 hour reaction time over 3 steps. The …
substituted pyrazolo [1, 5-a] pyrimidines in a total of 1 hour reaction time over 3 steps. The …
Прогноз біологічної активності похідних спірохіназолонів як інгібіторів протеїнкіназ FGFR1 і СК2
OK Farat, SA Varenychenko… - Current issues in …, 2020 - pharmed.zsmu.edu.ua
The purpose. The search for FGFR1 and CK2 protein kinase inhibitors were performed
among spiroquinazolone derivatives using receptor-oriented virtual screening and in vitro …
among spiroquinazolone derivatives using receptor-oriented virtual screening and in vitro …
Development of Chemical Scaffolds for Kinase Inhibition Through Scaffold Hopping and Rational Design
J Duncan - 2020 - unsworks.unsw.edu.au
The research of this thesis describes the development of small molecule scaffolds for use as
potent inhibitors of CLK1, DYRK1a and Pim-1 kinases. Chapter 1 details the motivations of …
potent inhibitors of CLK1, DYRK1a and Pim-1 kinases. Chapter 1 details the motivations of …
[PDF][PDF] Розробка інгібіторів протеїнкінази СК2 за допомогою фармакофорного моделювання
СА Старосила, ГП Волинець… - Ukrainica …, 2014 - bioorganica.org.ua
Протеїнкіназа СК2—це убіквістична, висококонсервативна серин треонінова кіназа, що
бере участь у регуляції росту, проліферації, загибелі клітин і підтриманні їх …
бере участь у регуляції росту, проліферації, загибелі клітин і підтриманні їх …