Simple Summary Lung adenocarcinoma (LUAD) is the major subtype of lung cancer and
represents the deadliest human cancer, affecting current-, ex-, and even non-smokers …

Thirty-four years since its discovery, NF-κB remains a transcription factor with great potential
for cancer therapy. However, NF-κB–targeted therapies have yet to find a way to be clinically …

Although the lung is the most common metastatic site for cancer cells, biologic mechanisms
regulating lung metastasis are not fully understood. Using heterotopic and intravenous …

Although epithelial NF-κB signaling is important for lung carcinogenesis, NF-κB inhibitors
are ineffective for cancer treatment. To explain this paradox, we studied mice with genetic …

Tumour promoting inflammation is widely recognized as a hallmark of cancer. The source of
this chronic inflammation in cancer has been ascribed to the progressive activation over time …

Mechanisms driving persistent airway inflammation in chronic obstructive pulmonary
disease (COPD) are incompletely understood. As secretory immunoglobulin A (SIgA) …

The NF-κB family of transcription factors regulate the expression of genes encoding proteins
and microRNAs (miRNA, miR) precursors that may either positively or negatively regulate a …

Respiratory diseases remain a major cause of morbidity and mortality worldwide. An
imbalance of zinc, an essential trace element, is associated with a variety of lung diseases …

Nasopharyngeal carcinoma (NPC) is a unique EBV‐associated subtype of head and neck
cancer, which has the highest incidence in Southern China and eastern South Asia. The …

NF-κB is considered a major contributor to tumor development, but how this factor functions
in the initial stages of oncogenesis is not clear. In a model of Ras-induced transformation …