Role of Nrf2 in aging, Alzheimer's and other neurodegenerative diseases
M George, M Tharakan, J Culberson, AP Reddy… - Ageing Research …, 2022 - Elsevier
Abstract Nuclear Factor-Erythroid Factor 2 (Nrf2) is an important transcription factor that
regulates the expression of large number of genes in healthy and disease states. Nrf2 is …
regulates the expression of large number of genes in healthy and disease states. Nrf2 is …
Implications of gut microbiota in neurodegenerative diseases
H Zhang, Y Chen, Z Wang, G Xie, M Liu… - Frontiers in …, 2022 - frontiersin.org
The morbidity associated with neurodegenerative diseases (NDs) is increasing, posing a
threat to the mental and physical quality of life of humans. The crucial effect of microbiota on …
threat to the mental and physical quality of life of humans. The crucial effect of microbiota on …
Microglial cGAS drives neuroinflammation in the MPTP mouse models of Parkinson's disease
C Ma, Y Liu, S Li, C Ma, J Huang, S Wen… - CNS Neuroscience …, 2023 - Wiley Online Library
Background Neuroinflammation has been widely accepted as a cause of the degenerative
process. Increasing interest has been devoted to developing intervening therapeutics for …
process. Increasing interest has been devoted to developing intervening therapeutics for …
Exendin-4 and linagliptin attenuate neuroinflammation in a mouse model of Parkinson's disease
HY Yu, T Sun, Z Wang, H Li, D Xu, J An… - Neural Regeneration …, 2023 - journals.lww.com
Use of glucagon-like peptide-1 receptor agonist or dipeptidyl peptidase 4 inhibitor has been
shown to lower the incidence of Parkinson's disease in patients with diabetes mellitus …
shown to lower the incidence of Parkinson's disease in patients with diabetes mellitus …
Parkinson's disease: potential actions of lithium by targeting the WNT/β-catenin pathway, oxidative stress, inflammation and glutamatergic pathway
A Vallée, JN Vallée, Y Lecarpentier - Cells, 2021 - mdpi.com
Parkinson's disease (PD) is one of the major neurodegenerative diseases (ND) which
presents a progressive neurodegeneration characterized by loss of dopamine in the …
presents a progressive neurodegeneration characterized by loss of dopamine in the …
Mitochondrial CHCHD2: disease-associated mutations, physiological functions, and current animal models
TR Kee, P Espinoza Gonzalez, JL Wehinger… - Frontiers in aging …, 2021 - frontiersin.org
Rare mutations in the mitochondrial protein coiled-coil-helix-coiled-coil-helix domain
containing 2 (CHCHD2) are associated with Parkinson's disease (PD) and other Lewy body …
containing 2 (CHCHD2) are associated with Parkinson's disease (PD) and other Lewy body …
Novel flavonoid 1, 3, 4-oxadiazole derivatives ameliorate MPTP-induced Parkinson's disease via Nrf2/NF-κB signaling pathway
HW Meng, ZB Shen, XS Meng, ZQ Yin, XR Wang… - Bioorganic …, 2023 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disorder with a complex
etiology. Neuroinflammation and oxidative stress are important factors driving the …
etiology. Neuroinflammation and oxidative stress are important factors driving the …
Parkinson's disease model in zebrafish using intraperitoneal MPTP injection
Introduction Parkinson's disease (PD) is the second most common neurodegenerative
disease that severely affects the quality of life of patients and their family members …
disease that severely affects the quality of life of patients and their family members …
[HTML][HTML] Tricin promoted ATG-7 dependent autophagic degradation of α-synuclein and dopamine release for improving cognitive and motor deficits in Parkinson's …
X Wang, W Hu, L Qu, J Wang, A Wu, HH Lo… - Pharmacological …, 2023 - Elsevier
Tricin, a natural nontoxic flavonoid distributed in grasses and euphorbia plants, has been
reported to scavenge free radicals, possess anti-inflammatory and antioxidative effects …
reported to scavenge free radicals, possess anti-inflammatory and antioxidative effects …
Curcumin regulates gut microbiota and exerts a neuroprotective effect in the MPTP model of Parkinson's disease
H Zhu, H Zhang, B Hou, B Xu, L Ji… - … and Alternative Medicine, 2022 - Wiley Online Library
Objectives. The experiment aimed to explore the effects of curcumin on motor impairment,
dopamine neurons, and gut microbiota in the 1‐methyl‐4‐phenyl‐1, 2, 3, 6 …
dopamine neurons, and gut microbiota in the 1‐methyl‐4‐phenyl‐1, 2, 3, 6 …