Role of Nrf2 in aging, Alzheimer's and other neurodegenerative diseases

M George, M Tharakan, J Culberson, AP Reddy… - Ageing Research …, 2022 - Elsevier
Abstract Nuclear Factor-Erythroid Factor 2 (Nrf2) is an important transcription factor that
regulates the expression of large number of genes in healthy and disease states. Nrf2 is …

Implications of gut microbiota in neurodegenerative diseases

H Zhang, Y Chen, Z Wang, G Xie, M Liu… - Frontiers in …, 2022 - frontiersin.org
The morbidity associated with neurodegenerative diseases (NDs) is increasing, posing a
threat to the mental and physical quality of life of humans. The crucial effect of microbiota on …

Microglial cGAS drives neuroinflammation in the MPTP mouse models of Parkinson's disease

C Ma, Y Liu, S Li, C Ma, J Huang, S Wen… - CNS Neuroscience …, 2023 - Wiley Online Library
Background Neuroinflammation has been widely accepted as a cause of the degenerative
process. Increasing interest has been devoted to developing intervening therapeutics for …

Exendin-4 and linagliptin attenuate neuroinflammation in a mouse model of Parkinson's disease

HY Yu, T Sun, Z Wang, H Li, D Xu, J An… - Neural Regeneration …, 2023 - journals.lww.com
Use of glucagon-like peptide-1 receptor agonist or dipeptidyl peptidase 4 inhibitor has been
shown to lower the incidence of Parkinson's disease in patients with diabetes mellitus …

Parkinson's disease: potential actions of lithium by targeting the WNT/β-catenin pathway, oxidative stress, inflammation and glutamatergic pathway

A Vallée, JN Vallée, Y Lecarpentier - Cells, 2021 - mdpi.com
Parkinson's disease (PD) is one of the major neurodegenerative diseases (ND) which
presents a progressive neurodegeneration characterized by loss of dopamine in the …

Mitochondrial CHCHD2: disease-associated mutations, physiological functions, and current animal models

TR Kee, P Espinoza Gonzalez, JL Wehinger… - Frontiers in aging …, 2021 - frontiersin.org
Rare mutations in the mitochondrial protein coiled-coil-helix-coiled-coil-helix domain
containing 2 (CHCHD2) are associated with Parkinson's disease (PD) and other Lewy body …

Novel flavonoid 1, 3, 4-oxadiazole derivatives ameliorate MPTP-induced Parkinson's disease via Nrf2/NF-κB signaling pathway

HW Meng, ZB Shen, XS Meng, ZQ Yin, XR Wang… - Bioorganic …, 2023 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disorder with a complex
etiology. Neuroinflammation and oxidative stress are important factors driving the …

Parkinson's disease model in zebrafish using intraperitoneal MPTP injection

NA Omar, J Kumar, SL Teoh - Frontiers in Neuroscience, 2023 - frontiersin.org
Introduction Parkinson's disease (PD) is the second most common neurodegenerative
disease that severely affects the quality of life of patients and their family members …

[HTML][HTML] Tricin promoted ATG-7 dependent autophagic degradation of α-synuclein and dopamine release for improving cognitive and motor deficits in Parkinson's …

X Wang, W Hu, L Qu, J Wang, A Wu, HH Lo… - Pharmacological …, 2023 - Elsevier
Tricin, a natural nontoxic flavonoid distributed in grasses and euphorbia plants, has been
reported to scavenge free radicals, possess anti-inflammatory and antioxidative effects …

Curcumin regulates gut microbiota and exerts a neuroprotective effect in the MPTP model of Parkinson's disease

H Zhu, H Zhang, B Hou, B Xu, L Ji… - … and Alternative Medicine, 2022 - Wiley Online Library
Objectives. The experiment aimed to explore the effects of curcumin on motor impairment,
dopamine neurons, and gut microbiota in the 1‐methyl‐4‐phenyl‐1, 2, 3, 6 …