Protective mechanism of Paeonol on central nervous system

R Wu, Y Liu, F Zhang, S Dai, X Xue… - Phytotherapy …, 2024 - Wiley Online Library
Cerebrovascular diseases involve neuronal damage, resulting in degenerative neuropathy
and posing a serious threat to human health. The discovery of effective drug components …

[HTML][HTML] Targeting Mitochondrial Dysfunction and Reactive Oxygen Species for Neurodegenerative Disease Treatment

EH Choi, MH Kim, SJ Park - International Journal of Molecular Sciences, 2024 - mdpi.com
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common
neurodegenerative diseases, and they affect millions of people worldwide, particularly older …

Oral administration of sophoricoside (SOP) inhibits neuronal damage and neuroinflammation to curb neurodegeneration in Parkinson's disease

H Wang, D He, Z Li, X Gao, S Yang, M Cui, B Ye… - Chemico-Biological …, 2023 - Elsevier
Neuronal apoptosis and neuroinflammation are key factors involved in the pathological
changes of Parkinson's disease (PD). Sophoricoside (SOP) has shown anti-inflammatory …

Mapping the Research of Ferroptosis in Parkinson's Disease from 2013 to 2023: A Scientometric Review

Y Chen, Z Wu, S Li, Q Chen, L Wang, X Qi… - Drug Design …, 2024 - Taylor & Francis
Methods Related studies on PD and ferroptosis were searched in Web of Science Core
Collection (WOSCC) from inception to 2023. VOSviewer, CiteSpace, RStudio, and Scimago …

A naturally occurring variant of SHLP2 is a protective factor in Parkinson's disease

SJ Kim, B Miller, NG Hartel, R Ramirez, RG Braniff… - Molecular …, 2024 - nature.com
Mitochondrial DNA single nucleotide polymorphisms (mtSNPs) have been associated with a
reduced risk of developing Parkinson's disease (PD), yet the underlying mechanisms remain …

Hispidin in the Medicinal Fungus Protects Dopaminergic Neurons from JNK Activation-Regulated Mitochondrial-Dependent Apoptosis in an MPP+-Induced In Vitro …

MC Lai, WY Liu, SS Liou, IM Liu - Nutrients, 2023 - mdpi.com
Degenerative diseases of the brain include Parkinson's disease (PD), which is associated
with moveable signs and is still incurable. Hispidin belongs to polyphenol and originates …

Role of Nutraceuticals and Physical Activity in Parkinson's Disease Risk and Lifestyle Management

P Wal, H Vig, A Wal, S Rathore, SS Pandey… - Current Aging …, 2023 - ingentaconnect.com
Background: Parkinson's disease is a complicated, gradually progressive neurological
illness characterized by locomotor and non-motor symptomatology that impedes daily …

Targeting the Labile Iron Pool with Engineered DFO Nanosheets to Inhibit Ferroptosis for Parkinson's Disease Therapy

L Lei, J Yuan, Z Dai, S Xiang, Q Tu, X Cui… - Advanced …, 2024 - Wiley Online Library
Ferroptosis in neurons is considered one of the key factors that induces Parkinson's disease
(PD), which is caused by excessive iron accumulation in the intracellular labile iron pool …

Pathological characterization of a novel mouse model expressing the PD-linked CHCHD2-T61I mutation

TR Kee, JL Wehinger, PE Gonzalez… - Human molecular …, 2022 - academic.oup.com
Abstract Coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) is a
mitochondrial protein that plays important roles in cristae structure, oxidative …

Ndfip1 protected dopaminergic neurons via regulating mitochondrial function and ferroptosis in Parkinson's disease

X Fu, L Qu, H Xu, J Xie - Experimental Neurology, 2024 - Elsevier
Increasing evidence has shown that mitochondrial dysfunction and iron accumulation
contribute to the pathogenesis of Parkinson's disease (PD). Nedd4 family interacting protein …