Cytarabine prevents neuronal damage by enhancing AMPK to stimulate PINK1/Parkin-involved mitophagy In Parkinson's disease model
L Li, Y Zhang, Z Chen, C Xu, Z Xu, H Pei… - European Journal of …, 2024 - Elsevier
Parkinson's disease (PD) is a common age-related neurodegenerative disorder, which may
be largely due to the mitochondrial dysfunction and impaired mitophagy. Thus, it is of great …
be largely due to the mitochondrial dysfunction and impaired mitophagy. Thus, it is of great …
[HTML][HTML] Neuroprotective effect of rice bran enzymatic extract-supplemented diets in a murine model of Parkinsońs disease
Neurodegenerative disorders such as Parkinson's disease, present a global health concern
with limited therapeutic options. In this context, dietary interventions have emerged as a …
with limited therapeutic options. In this context, dietary interventions have emerged as a …
[HTML][HTML] Levodopa improves behavioral deficits of mice with Parkinson's disease symptoms via curbing NLRP3 inflammasome activation and enhancing tyrosine …
X Chen, Z Wang, W Yang, Y Fu - Journal of Integrative Neuroscience, 2024 - imrpress.com
Objective: Levodopa (L-DOPA) is the primary treatment for Parkinson's disease (PD).
Nevertheless, the underlying mechanism of its action is not entirely learned. This study aims …
Nevertheless, the underlying mechanism of its action is not entirely learned. This study aims …
[HTML][HTML] 3-Tetrazolyl-β-carboline derivatives as potential neuroprotective agents
JLP Ribeiro, I Costa, R Silva, SMM Lopes… - Bioorganic & Medicinal …, 2024 - Elsevier
Tetrazolyl-β-carbolines were prepared by the Pictet-Spengler approach using a tryptophan
analogue as building block, in which the carboxylic acid was replaced by the bioisosteric …
analogue as building block, in which the carboxylic acid was replaced by the bioisosteric …
Nigrostriatal Inflammation Is Associated with Nonmotor Symptoms in an Experimental Model of Prodromal Parkinson's Disease
B da Silva Oliveira, EC de Brito Toscano, LKS Abreu… - Neuroscience, 2024 - Elsevier
Recent evidence has supported a pathogenic role for neuroinflammation in Parkinson's
disease (PD). Inflammatory response has been associated with symptoms and subtypes of …
disease (PD). Inflammatory response has been associated with symptoms and subtypes of …
[HTML][HTML] The regulation of NFKB1 on CD200R1 expression and their potential roles in Parkinson's disease
S Lin, Y Shu, R Shen, Y Zhou… - Journal of …, 2024 - jneuroinflammation.biomedcentral …
Overactivated microglia are a key contributor to Parkinson's disease (PD) by inducing
neuroinflammation. CD200R1, a membrane glycoprotein mainly found on microglia, is …
neuroinflammation. CD200R1, a membrane glycoprotein mainly found on microglia, is …
Protopanaxadiols Eliminate Behavioral Impairments and Mitochondrial Dysfunction in Parkinson's Disease Mice Model
J Zhao, J Wang, K Zhao, Y Zhang, W Hu - Neurochemical Research, 2024 - Springer
Currently, there are no effective therapies to cure Parkinson's disease (PD), which is the
second most common neurodegenerative disease primarily characterized by motor …
second most common neurodegenerative disease primarily characterized by motor …
Levistilide A Exerts a Neuroprotective Effect by Suppressing Glucose Metabolism Reprogramming and Preventing Microglia Polarization Shift: Implications for …
M Zhang, C Duan, W Lin, H Wu, L Chen, H Guo, M Yu… - Molecules, 2024 - mdpi.com
The microglia, displaying diverse phenotypes, play a significant regulatory role in the
development, progression, and prognosis of Parkinson's disease. Research has established …
development, progression, and prognosis of Parkinson's disease. Research has established …
Identification and optimization of nitrophenolic analogues as dopamine metabolic enzyme inhibitors for the treatment of Parkinson's disease
M Zou, Y Wu, Y Lan, H Xie, H Sun, W Liu, F Feng… - Bioorganic …, 2024 - Elsevier
Progressive loss of dopaminergic neurons leads to the depletion of the striatal
neurotransmitter dopamine, which is the main cause of Parkinson's disease (PD) motor …
neurotransmitter dopamine, which is the main cause of Parkinson's disease (PD) motor …
Biological interactions and attenuation of MPTP-induced toxicity in Drosophila melanogaster by trans-astaxanthin
T Omotayo, TA Otenaike, AO Adedara… - Neuroscience …, 2023 - Elsevier
Trans-astaxanthin (TA) is a carotenoid with amphipathic chemical structure found in yeast,
and aquatic organisms. It is known to possess both antioxidative and anti-inflammatory …
and aquatic organisms. It is known to possess both antioxidative and anti-inflammatory …