Abstract In China, Parkinson's disease (PD) is the second most prevalent central nervous
system (CNS) degenerative illness affecting middle-aged and older persons. Movement …

methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) mice model is one of the most common
animal models for Parkinson's disease (PD). It is classified into three types: acute, subacute …

Cognitive impairment is an important component of non motor symptoms in Parkinson's
disease (PD), and if not addressed in a timely manner, it can easily progress to dementia …

Elevated ER stress has been linked to the pathogenesis of several disease conditions
including neurodegeneration. In this study, we have holistically determined the differential …

Abstract Background Circulating zinc (Zn) concentrations are lower than normal in patients
with Parkinson disease (PD). It is unknown whether Zn deficiency increases the …

EP1 receptor belongs to prostanoid receptors and is activated by prostaglandin E2. The
receptor performs contrasting functions in central nervous system (CNS) and other tissues …

Parkinson's disease (PD) is a neurodegenerative disease that affects dopaminergic
neurons, thus impairing dopaminergic signalling. Quercetin (QUE) has antioxidant and …

Parkinson's disease (PD) entails the progressive loss of dopaminergic (DA) neurons in the
substantia nigra pars compacta (SNc), leading to movement-related impairments. Accurate …

Autophagy is a self-destructive cellular process that removes essential metabolites and
waste from inside the cell to maintain cellular health. Mitophagy is the process by which …

Methods We studied C. elegans that lack the ability to sequester dopamine (OK411) and that
overproduce dopamine (UA57) and a novel strain (MBIA) generated by the genetic crossing …