Spatially selective firing of place cells, grid cells, boundary vector/border cells and head
direction cells constitutes the basic building blocks of a canonical spatial navigation system …

Two neural systems are known to encode self-location in the brain: Place cells in the
hippocampus encode unique locations in unique environments, whereas grid cells, border …

In this review we discuss converging evidence from human and rodent research
demonstrating how path integration (PI) is impaired in healthy aging and Alzheimer's …

The mediodorsal thalamus (MD) and anterior thalamic nuclei (ATN) are two adjacent brain
nodes that support our ability to make decisions, learn, update information, form and retrieve …

A novel perspective on the biological mechanisms of episodic memory, focusing on the
encoding and retrieval of spatiotemporal trajectories. Episodic memory proves essential for …

The medial entorhinal cortex (MEC) creates a map of local space, based on the firing
patterns of grid, head-direction (HD), border, and object-vector (OV) cells. How these cell …

The role of the hippocampus in spatial cognition is incontrovertible yet controversial. Place
cells, initially thought to be location-specifiers, turn out to respond promiscuously to a wide …

The spatial receptive fields of neurons in medial entorhinal cortex layer II (MECII) and in the
hippocampus suggest general and environment-specific maps of space, respectively …

This review focuses on the functional and anatomical links between the cerebellum and the
hippocampus and the role of their interplay in goal-directed navigation and spatial cognition …

Perineuronal nets (PNNs) are specialized extracellular matrix (ECM) structures that
condense around the soma and proximal dendrites of subpopulations of neurons. Emerging …