Highlights•Azole antifungals can increase blood concentrations of immunosuppressants.•
Tools to assess interactions between azoles and immunosuppressants are presented.•A …

Calcineurin inhibitors (CNIs), such as cyclosporine A and tacrolimus, are widely used
immunosuppressive agents for the prevention of post-transplantation rejection and have …

Aims The aims of the present study were to characterize the pharmacokinetics of
voriconazole in renal transplant recipients and to identify factors significantly affecting …

Introduction: Polymorphisms in genes responsible for the metabolism and transport of
tacrolimus have been demonstrated to influence clinical outcomes for patients following …

Aims Voriconazole remains the mainstay for the treatment of invasive fungal infections in
heart transplant patients and can significantly increase tacrolimus exposure because of drug …

Single nucleotide polymorphisms in drug-metabolizing genes may affect tacrolimus
pharmacokinetics. Here, we investigated the influence of genotypes of CYP3A5, CYP2C19 …

Aim: Multiple genetic variants have been associated with variation in tacrolimus (TAC)
trough concentrations. Unfortunately, additional studies do not confirm these associations …

Tacrolimus is prescribed to the majority of transplant recipients to prevent graft rejection, and
although patients are maintained on oral administration, nonoral routes of administration are …

Introduction: Recipients of hematopoietic stem cell transplantation (HSCT) are exposed to
numerous drugs in both pre-and post-transplantation period, which creates an opportunity …

Background and Objective: Tacrolimus, a calcineurin inhibitor widely used as a potent
immunosuppressant to prevent graft rejection, exhibits nonlinear kinetics in patients with …