Is the glymphatic system the missing link between sleep impairments and neurological disorders? Examining the implications and uncertainties
J Christensen, GR Yamakawa, SR Shultz… - Progress in …, 2021 - Elsevier
Until recently, both the purpose of the biological need for sleep and the mechanism by which
the central nervous system eliminated metabolic waste products were unknown. The …
the central nervous system eliminated metabolic waste products were unknown. The …
Crosstalk of brain and bone—clinical observations and their molecular bases
E Otto, PR Knapstein, D Jahn, J Appelt… - International journal of …, 2020 - mdpi.com
As brain and bone disorders represent major health issues worldwide, substantial clinical
investigations demonstrated a bidirectional crosstalk on several levels, mechanistically …
investigations demonstrated a bidirectional crosstalk on several levels, mechanistically …
[Retracted] Glymphatic System: Emerging Therapeutic Target for Neurological Diseases
X Xuan, G Zhou, C Chen, A Shao… - Oxidative Medicine …, 2022 - Wiley Online Library
The newly discovered glymphatic system acts as pseudolymphatic vessels subserving brain
waste clearance and is functionally dependent on astrocytic aquaporin‐4 channels. The …
waste clearance and is functionally dependent on astrocytic aquaporin‐4 channels. The …
Clinical relevance of behavior testing in animal models of traumatic brain injury
Traumatic brain injury (TBI) is a leading cause of morbidity worldwide, with patients often
suffering from consequences such as cognitive deficits, social abnormalities, anxiety …
suffering from consequences such as cognitive deficits, social abnormalities, anxiety …
Associations of chronic pain with psychosocial outcomes after traumatic brain injury: a NIDILRR and VA TBI Model Systems Collaborative Project
R Hanks, JM Ketchum, M Peckham… - The Journal of Head …, 2024 - journals.lww.com
Objective: To examine the differences in participation, life satisfaction, and psychosocial
outcomes among individuals with traumatic brain injury (TBI) endorsing current, past, or no …
outcomes among individuals with traumatic brain injury (TBI) endorsing current, past, or no …
Will sirtuins be promising therapeutic targets for TBI and associated neurodegenerative diseases?
Q Yang, Y Zhou, Y Sun, Y Luo, Y Shen… - Frontiers in …, 2020 - frontiersin.org
Traumatic brain injury (TBI), a leading cause of morbidity worldwide, induces mechanical,
persistent structural, and metabolic abnormalities in neurons and other brain-resident cells …
persistent structural, and metabolic abnormalities in neurons and other brain-resident cells …
[HTML][HTML] The interaction of the circadian and immune system: Desynchrony as a pathological outcome to traumatic brain injury
Traumatic brain injury (TBI) is a complex and costly worldwide phenomenon that can lead to
many negative health outcomes including disrupted circadian function. There is a …
many negative health outcomes including disrupted circadian function. There is a …
Persistent neurovascular unit dysfunction: pathophysiological substrate and trigger for late-onset neurodegeneration after traumatic brain injury
Traumatic brain injury (TBI) represents one of the major causes of death worldwide and
leads to persisting neurological deficits in many of the survivors. One of the most significant …
leads to persisting neurological deficits in many of the survivors. One of the most significant …
Overview of systematic reviews: Management of common Traumatic Brain Injury-related complications
Background Many clinical interventions are trialled to manage medical complications
following Traumatic Brain Injury (TBI). However, published evidence for the effects of those …
following Traumatic Brain Injury (TBI). However, published evidence for the effects of those …
Future perspectives in spinal cord repair: brain as saviour? TSCI with concurrent TBI: pathophysiological interaction and impact on MSC treatment
Traumatic spinal cord injury (TSCI), commonly caused by high energy trauma in young
active patients, is frequently accompanied by traumatic brain injury (TBI). Although …
active patients, is frequently accompanied by traumatic brain injury (TBI). Although …