Is the glymphatic system the missing link between sleep impairments and neurological disorders? Examining the implications and uncertainties

J Christensen, GR Yamakawa, SR Shultz… - Progress in …, 2021 - Elsevier
Until recently, both the purpose of the biological need for sleep and the mechanism by which
the central nervous system eliminated metabolic waste products were unknown. The …

Crosstalk of brain and bone—clinical observations and their molecular bases

E Otto, PR Knapstein, D Jahn, J Appelt… - International journal of …, 2020 - mdpi.com
As brain and bone disorders represent major health issues worldwide, substantial clinical
investigations demonstrated a bidirectional crosstalk on several levels, mechanistically …

[Retracted] Glymphatic System: Emerging Therapeutic Target for Neurological Diseases

X Xuan, G Zhou, C Chen, A Shao… - Oxidative Medicine …, 2022 - Wiley Online Library
The newly discovered glymphatic system acts as pseudolymphatic vessels subserving brain
waste clearance and is functionally dependent on astrocytic aquaporin‐4 channels. The …

Clinical relevance of behavior testing in animal models of traumatic brain injury

SR Shultz, SJ McDonald, F Corrigan… - Journal of …, 2020 - liebertpub.com
Traumatic brain injury (TBI) is a leading cause of morbidity worldwide, with patients often
suffering from consequences such as cognitive deficits, social abnormalities, anxiety …

Associations of chronic pain with psychosocial outcomes after traumatic brain injury: a NIDILRR and VA TBI Model Systems Collaborative Project

R Hanks, JM Ketchum, M Peckham… - The Journal of Head …, 2024 - journals.lww.com
Objective: To examine the differences in participation, life satisfaction, and psychosocial
outcomes among individuals with traumatic brain injury (TBI) endorsing current, past, or no …

Will sirtuins be promising therapeutic targets for TBI and associated neurodegenerative diseases?

Q Yang, Y Zhou, Y Sun, Y Luo, Y Shen… - Frontiers in …, 2020 - frontiersin.org
Traumatic brain injury (TBI), a leading cause of morbidity worldwide, induces mechanical,
persistent structural, and metabolic abnormalities in neurons and other brain-resident cells …

[HTML][HTML] The interaction of the circadian and immune system: Desynchrony as a pathological outcome to traumatic brain injury

GR Yamakawa, RD Brady, M Sun, SJ McDonald… - Neurobiology of sleep …, 2020 - Elsevier
Traumatic brain injury (TBI) is a complex and costly worldwide phenomenon that can lead to
many negative health outcomes including disrupted circadian function. There is a …

Persistent neurovascular unit dysfunction: pathophysiological substrate and trigger for late-onset neurodegeneration after traumatic brain injury

Y Zhou, Q Chen, Y Wang, H Wu, W Xu, Y Pan… - Frontiers in …, 2020 - frontiersin.org
Traumatic brain injury (TBI) represents one of the major causes of death worldwide and
leads to persisting neurological deficits in many of the survivors. One of the most significant …

Overview of systematic reviews: Management of common Traumatic Brain Injury-related complications

V Vasudevan, B Amatya, F Khan - PLoS one, 2022 - journals.plos.org
Background Many clinical interventions are trialled to manage medical complications
following Traumatic Brain Injury (TBI). However, published evidence for the effects of those …

Future perspectives in spinal cord repair: brain as saviour? TSCI with concurrent TBI: pathophysiological interaction and impact on MSC treatment

P Köhli, E Otto, D Jahn, MJ Reisener, J Appelt… - Cells, 2021 - mdpi.com
Traumatic spinal cord injury (TSCI), commonly caused by high energy trauma in young
active patients, is frequently accompanied by traumatic brain injury (TBI). Although …