Organoids and organ-on-chip technology for investigating host-microorganism interactions
Short abstract Recent advances in organoid and organ-on-chip (OoC) technologies offer an
unprecedented level of tissue mimicry. These models can recapitulate the diversity of …
unprecedented level of tissue mimicry. These models can recapitulate the diversity of …
[HTML][HTML] A 3D organoid platform that supports liver-stage P. falciparum infection can be used to identify intrahepatic antimalarial drugs
Malaria, a major public health burden, is caused by Plasmodium spp parasites that first
replicate in the human liver to establish infection before spreading to erythrocytes. Liver …
replicate in the human liver to establish infection before spreading to erythrocytes. Liver …
Modulation of host signalling pathways reveal a major role for Wnt signalling in the maturation of Plasmodium falciparum liver schizonts
A Kanyal, GJ van Gemert, H Wu, A van der Starre… - bioRxiv, 2024 - biorxiv.org
After infection of the human host, the initial stage of the Plasmodium falciparum (Pf) lifecycle
takes place in the liver. However, understanding of the host-parasite interaction has been …
takes place in the liver. However, understanding of the host-parasite interaction has been …
Human liver organoids are susceptible to Plasmodium vivax infection
N Nitaramorn, P Kobpornchai, N Tongkrajang… - 2024 - researchsquare.com
The eradication of Plasmodium vivax malaria iscomplicated due to the presence of
hypnozoites, the hidden dormant form of the parasite that is present in the liver. Currently …
hypnozoites, the hidden dormant form of the parasite that is present in the liver. Currently …