We studied a two-generation family presenting with conditions that included progressive
permanent weakness, myopathic myopathy, exercise-induced contracture before …

Background: Hypokalemic periodic paralysis (HypoPP) is associated with mutations in either
the CaV1. 1 calcium channel or the NaV1. 4 sodium channel. Some NaV1. 4 HypoPP …

The field of cellular calcium signaling has had a curious history. After its discovery∼ 120
years ago–it was a revolutionary discovery if ever there was one–it remained, essentially …

1 A truncated form of the rabbit α1S Ca2+ channel subunit (α1SΔC) was expressed with the
β1b, α2δ and γ auxiliary subunits in Xenopus laevis oocytes. After 5–7 days, skeletal muscle …

Ion channels are membrane proteins responsible for the passage of ions down their
electrochemical gradients and across biological membranes. In this, they generate and …

Familial periodic paralyses are typical channelopathies (ie, caused by functional
disturbances of ion channel proteins). The episodes of flaccid muscle weakness observed in …

Hypokalaemic periodic paralysis (HypoPP) is an autosomal dominant muscle disease which
has been linked to point mutations in the skeletal muscle L‐type calcium channel α 1 subunit …

This review focuses on the electrical properties of the transverse (T) tubular membrane of
skeletal muscle, with reference to the contribution of the T-tubular system (TTS) to the …

Hypokalaemic periodic paralysis (HypoPP) is an autosomal dominant disorder, which is
characterized by periodic attacks of muscle weakness associated with a decrease in the …

Rabbit cDNA of the α1 subunit of the skeletal muscle dihydropyridine (DHP) receptor was
functionally expressed in a muscular dysgenesis mouse (mdg) cell line, GLT. L-type calcium …