[HTML][HTML] Hallmarks and biomarkers of skin senescence: An updated review of skin senotherapeutics

D Bulbiankova, R Díaz-Puertas, FJ Álvarez-Martínez… - Antioxidants, 2023 - mdpi.com
Aging is a complex process characterized by an ongoing decline in physiological functions,
leading to degenerative diseases and an increased probability of death. Cellular …

[HTML][HTML] Senescence: pathogenic driver in chronic obstructive pulmonary disease

M Rivas, G Gupta, L Costanzo, H Ahmed, AE Wyman… - Medicina, 2022 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is recognized as a disease of accelerated
lung aging. Over the past two decades, mounting evidence suggests an accumulation of …

Hatching is modulated by microRNA-378a-3p derived from extracellular vesicles secreted by blastocysts

KC Pavani, T Meese, OB Pascottini… - Proceedings of the …, 2022 - National Acad Sciences
Extracellular vesicles (EVs) and their cargo microRNAs (miRNAs) are important regulators of
embryo development to the blastocyst stage and beyond. Before implantation can take …

FBXO43 variants in patients with female infertility characterized by early embryonic arrest

W Wang, W Wang, Y Xu, J Shi, J Fu, B Chen… - Human …, 2021 - academic.oup.com
STUDY QUESTION Can any new genetic factors responsible for early embryonic arrest in
infertile patients be identified, together with the mechanism of pathogenic variants …

[HTML][HTML] Endothelial senescence and its impact on angiogenesis in Alzheimer's disease

I Georgieva, J Tchekalarova, D Iliev… - International Journal of …, 2023 - mdpi.com
Endothelial cells are constantly exposed to environmental stress factors that, above a certain
threshold, trigger cellular senescence and apoptosis. The altered vascular function affects …

[HTML][HTML] Cathepsin-L secreted by high-quality bovine embryos exerts an embryotrophic effect in vitro

A Raes, E Wydooghe, KC Pavani… - International Journal of …, 2023 - mdpi.com
While human in vitro embryo production is generally performed individually, animal models
have shown that culturing embryos in groups improves blastocyst yield and quality …

[HTML][HTML] Pre-Implantation Bovine Embryo Evaluation—From Optics to Omics and Beyond

RAC Rabel, PV Marchioretto, EA Bangert, K Wilson… - Animals, 2023 - mdpi.com
Simple Summary With conventional breeding practices, even the best dairy/beef cows will
likely produce no more than half-a-dozen calves in their lifetimes; a crime, would you not …

[HTML][HTML] tRNAGlu-derived fragments from embryonic extracellular vesicles modulate bovine embryo hatching

Y Fan, KC Pavani, K Smits, A Van Soom… - Journal of Animal …, 2024 - Springer
Transfer RNA-derived small RNAs (tsRNAs) have been shown to be involved in early
embryo development and repression of endogenous retroelements in embryos and stem …

[HTML][HTML] Cumulus cell and oocyte gene expression in prepubertal gilts and sows identifies cumulus cells as a prime informative parameter of oocyte quality

LM Haug, RC Wilson, AH Gaustad, R Jochems… - Biology, 2023 - mdpi.com
Simple Summary Progress has been made in pig in vitro embryo production (IVEP) over the
years, but some of the remaining challenges are low embryo production rates compared to …

[HTML][HTML] Development of a microfluidic chip powered by EWOD for in vitro manipulation of bovine embryos

A Karcz, A Van Soom, K Smits, S Van Vlierberghe… - Biosensors, 2023 - mdpi.com
Digital microfluidics (DMF) holds great potential for the alleviation of laboratory procedures
in assisted reproductive technologies (ARTs). The electrowetting on dielectric (EWOD) …