The mucosal lining of the respiratory and digestive systems contains the largest and most
complex immune system in the body, but surprisingly little is known of the immune system …

Environmental allergens are an important cause of asthma and can contribute to loss of
asthma control and exacerbations. Allergen inhalation challenge has been a useful clinical …

Experimental mouse models of allergic asthma established almost 10 years ago offered new
opportunities to study disease pathogenesis and to develop new therapeutics. These …

The Runx3 transcription factor is a key regulator of lineage-specific gene expression in
several developmental pathways and could also be involved in autoimmunity. We report …

Asthma and rhinitis are complex, heterogeneous diseases characterized by chronic
inflammation of the upper and lower airways. While genome-wide association studies …

Chemokines and chemokine receptors are part of a complex network of molecules that play
a key role in leukocyte migration and activation. The chemokine family role is crucial in the …

Introduction Nanosized particles may enable therapeutic modulation of immune responses
by targeting dendritic cell (DC) networks in accessible organs such as the lung. To date …

Inhalation of antigenic matter stimulates rapid recruitment of dendritic cells (DCs) into the
lung. Recent studies propose that the chemokine CCL20 (macrophage inflammatory protein …

This study tested the hypotheses that chronic allergic inflammation induces not only
bronchial but also lung parenchyma remodeling, and that these histologic changes are …

Despite recent advances in the development of anti-asthmatic medication, asthma continues
to be a major health problem worldwide. The symptoms of asthmatic patients include …