Aging represents the major risk factor for the onset and/or progression of various disorders
including neurodegenerative diseases, metabolic disorders, and bone-related defects. As …

Cellular senescence is a complex biological process that leads to irreversible cell‐cycle
arrest. Various extrinsic and intrinsic insults are associated with the onset of cellular …

The role of post-transcriptional gene regulation in human brain development and
neurodevelopmental disorders remains mostly uncharacterized. ELAV-like RNA-binding …

Local regulation of synaptic efficacy is thought to be important for proper networking of
neurons and memory formation. Dysregulation of global translation influences long-term …

Abstract Alzheimer's disease (AD), the most common cause of dementia, is an irreversible
and progressive neurodegenerative disorder. It affects predominantly brain areas that are …

CLIP-seq experiments are currently the most important means for determining the binding
sites of RNA binding proteins on a genome-wide level. The computational analysis can be …

The RNA-binding protein HuD has been shown to play a crucial role in gene regulation in
the nervous system and is involved in various neurological and psychiatric diseases. In this …

TDP-43 is an RNA-binding protein involved in several steps of mRNA metabolism including
transcription, splicing and stability. It is also involved in ALS and FTD, neurodegenerative …

The evolution of humans brought about a co-occurring evolution of the human brain, which
is far larger and more complex than that of many other organisms. The brain has evolved …

Significance: Amyotrophic lateral sclerosis (ALS) is due to degeneration of upper and lower
motor neurons in the anterior horn of the spinal cord and in the motor cortex. Mechanisms …