Dearomatization reactions have become fundamental chemical transformations in organic
synthesis since they allow for the generation of three-dimensional complexity from two …

Visual kinetic analyses extract meaningful mechanistic information from experimental data
using the naked-eye comparison of appropriately modified progress reaction profiles. Basic …

Catalytic asymmetric transformations by dearomatization have developed into a widely
applicable synthetic strategy, but heavily relied on the use of arenes bearing a heteroatom …

Asymmetric allylic and propargylic substitutions have seen numerous applications in
synthetic chemistry, constructing stereogenic centres vicinal to unsaturated C–C bonds …

Background The chemistry and applications of 2-pyridone structures have recently attracted
a lot of attention due to their uses as synthetic intermediates and their biological importance …

Nucleophilic displacement of the propargylic alcohol is one of the sought-after methods in
the current scenario. The highly nucleophilic alkyne functional moiety along with its …

Impressive progress has been made in the copper‐catalyzed asymmetric propargylic
substitution (APS) reaction, but its use in remote asymmetric yne‐allylic substitution remains …

Development of transition metal-catalyzed propargylic substitution reactions is still in
progress as a novel synthetic tool, while a variety of allylic substitution reactions have been …

A ruthenium-catalyzed highly chemoselective N-alkylation of 2-pyridones has been
developed, affording N-alkylated 2-pyridone derivatives in good yields and excellent N …

Despite binuclear Cu active sites present in some biological and heterogeneous catalysts,
the development of chiral binuclear copper catalysts is still in its infancy and remains a …