From vaccines to memory and back
Vaccines work by eliciting an immune response and consequent immunological memory
that mediates protection from infection or disease. Recently, new methods have been …
that mediates protection from infection or disease. Recently, new methods have been …
Malaria: progress, perils, and prospects for eradication
There are still approximately 500 million cases of malaria and 1 million deaths from malaria
each year. Yet recently, malaria incidence has been dramatically reduced in some parts of …
each year. Yet recently, malaria incidence has been dramatically reduced in some parts of …
Immunogenicity of the RTS, S/AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of data from a phase 3 randomised …
Summary Background The RTS, S/AS01 malaria vaccine targets the circumsporozoite
protein, inducing antibodies associated with the prevention of Plasmodium falciparum …
protein, inducing antibodies associated with the prevention of Plasmodium falciparum …
Viruses as vaccine vectors for infectious diseases and cancer
Recent developments in the use of viruses as vaccine vectors have been facilitated by a
better understanding of viral biology. Advances occur as we gain greater insight into the …
better understanding of viral biology. Advances occur as we gain greater insight into the …
From the circumsporozoite protein to the RTS, S/AS candidate vaccine
J Cohen, V Nussenzweig, J Vekemans, A Leach - Human vaccines, 2010 - Taylor & Francis
The RTS, S/AS01E malaria vaccine candidate has recently entered phase 3 testing.
Reaching this important milestone is the culmination of more than 20 years of research and …
Reaching this important milestone is the culmination of more than 20 years of research and …
Plasmodium sporozoites trickle out of the injection site
LM Yamauchi, A Coppi, G Snounou… - Cellular …, 2007 - Wiley Online Library
Plasmodium sporozoites make a remarkable journey from the skin, where they are
deposited by an infected Anopheline mosquito, to the liver, where they invade hepatocytes …
deposited by an infected Anopheline mosquito, to the liver, where they invade hepatocytes …
The Relationship between RTS,S Vaccine-Induced Antibodies, CD4+ T Cell Responses and Protection against Plasmodium falciparum Infection
Vaccination with the pre-erythrocytic malaria vaccine RTS, S induces high levels of
antibodies and CD4+ T cells specific for the circumsporozoite protein (CSP). Using a …
antibodies and CD4+ T cells specific for the circumsporozoite protein (CSP). Using a …
Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria
NW Schmidt, RL Podyminogin… - Proceedings of the …, 2008 - National Acad Sciences
Infection of mice with sporozoites of Plasmodium berghei or Plasmodium yoelii has been
used extensively to evaluate liver-stage protection by candidate preerythrocytic malaria …
used extensively to evaluate liver-stage protection by candidate preerythrocytic malaria …
Memory CD8+ T cell differentiation
JJ Obar, L Lefrançois - Annals of the New York Academy of …, 2010 - Wiley Online Library
In response to infection or effective vaccination, naive antigen‐specific CD8+ T cells
undergo a dramatic highly orchestrated activation process. Initial encounter with an …
undergo a dramatic highly orchestrated activation process. Initial encounter with an …
Prime-boost vectored malaria vaccines: progress and prospects
The difficulty of inducing protective immunity through antibodies against sporozoites led to
efforts to assess vectored vaccines as a means of inducing protective T cell immunity against …
efforts to assess vectored vaccines as a means of inducing protective T cell immunity against …