Over the past several decades, the incidence of early-onset cancers, often defined as
cancers diagnosed in adults< 50 years of age, in the breast, colorectum, endometrium …

Food components in our diet provide not only necessary nutrients to our body but also
substrates for the mutualistic microbial flora in our gastrointestinal tract, termed the gut …

The incidence of early-onset colorectal cancer (CRC), which occurs in individuals< 50 years
of age, has been increasing worldwide and particularly in high-income countries. The …

A higher incidence of colorectal cancer (CRC) is found in males compared to females.
Young women (18–44 years) with CRC have a better survival outcome compared to men of …

Background & Aims Long-term outcomes of patients with branch-duct intraductal papillary
mucinous neoplasms (IPMNs), particularly those after 5 years of surveillance, have not been …

Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that block immune inhibitory
pathways. Administration of ICIs augments T cell-mediated immune responses against …

Gastrointestinal (GI) cancers, especially gastric cancer and colorectal cancer (CRC),
represent a major global health burden. A large population of microorganisms residing in …

Background & Aims Evidence supports a carcinogenic role of Escherichia coli carrying the
pks island that encodes enzymes for colibactin biosynthesis. We hypothesized that the …

High inter-patient variability and high spatial heterogeneity are features of colorectal cancer
(CRC). This may influence the molecular characterization of tumor tissue, now mandatory for …

Colorectal cancer (CRC) is the third most common and the second most fatal cancer. In
recent years, more attention has been directed toward the role of gut microbiota in the …