[HTML][HTML] An ecotoxicological view on neurotoxicity assessment

JB Legradi, C Di Paolo, MHS Kraak… - Environmental Sciences …, 2018 - Springer
The numbers of potential neurotoxicants in the environment are raising and pose a great risk
for humans and the environment. Currently neurotoxicity assessment is mostly performed to …

Approaches to test the neurotoxicity of environmental contaminants in the zebrafish model: From behavior to molecular mechanisms

JA Fitzgerald, S Könemann… - Environmental …, 2021 - Wiley Online Library
The occurrence of neuroactive chemicals in the aquatic environment is on the rise and
poses a potential threat to aquatic biota of currently unpredictable outcome. In particular …

Simultaneous whole-animal 3D imaging of neuronal activity using light-field microscopy

R Prevedel, YG Yoon, M Hoffmann, N Pak… - Nature …, 2014 - nature.com
High-speed, large-scale three-dimensional (3D) imaging of neuronal activity poses a major
challenge in neuroscience. Here we demonstrate simultaneous functional imaging of …

[HTML][HTML] Zebrafish behavior: opportunities and challenges

MB Orger, GG de Polavieja - Annual review of neuroscience, 2017 - annualreviews.org
A great challenge in neuroscience is understanding how activity in the brain gives rise to
behavior. The zebrafish is an ideal vertebrate model to address this challenge, thanks to the …

Animal models in epilepsy research: legacies and new directions

BP Grone, SC Baraban - Nature neuroscience, 2015 - nature.com
Human epilepsies encompass a wide variety of clinical, behavioral and electrical
manifestations. Correspondingly, studies of this disease in nonhuman animals have brought …

[HTML][HTML] Whole-brain activity maps reveal stereotyped, distributed networks for visuomotor behavior

R Portugues, CE Feierstein, F Engert, MB Orger - Neuron, 2014 - cell.com
Most behaviors, even simple innate reflexes, are mediated by circuits of neurons spanning
areas throughout the brain. However, in most cases, the distribution and dynamics of firing …

[HTML][HTML] Zebrafish models of neurodevelopmental disorders: limitations and benefits of current tools and techniques

R Vaz, W Hofmeister, A Lindstrand - International journal of molecular …, 2019 - mdpi.com
For the past few years there has been an exponential increase in the use of animal models
to confirm the pathogenicity of candidate disease-causing genetic variants found in patients …

[HTML][HTML] Functional architecture of an optic flow-responsive area that drives horizontal eye movements in zebrafish

F Kubo, B Hablitzel, M Dal Maschio, W Driever, H Baier… - Neuron, 2014 - cell.com
Animals respond to whole-field visual motion with compensatory eye and body movements
in order to stabilize both their gaze and position with respect to their surroundings. In …

Integrative whole-brain neuroscience in larval zebrafish

GC Vanwalleghem, MB Ahrens, EK Scott - Current opinion in neurobiology, 2018 - Elsevier
Highlights•Neural activity can now be recorded in all cells of larval zebrafish
brains.•Neurons involved in sensation, motor control, and learning have been …

[HTML][HTML] Cerebellar neurodynamics predict decision timing and outcome on the single-trial level

Q Lin, J Manley, M Helmreich, F Schlumm, JM Li… - Cell, 2020 - cell.com
Goal-directed behavior requires the interaction of multiple brain regions. How these regions
and their interactions with brain-wide activity drive action selection is less understood. We …