Cu (I)-catalyzed click chemistry in glycoscience and their diverse applications
Copper (I)-catalyzed 1, 3-dipolar cycloaddition between organic azides and terminal
alkynes, commonly known as CuAAC or click chemistry, has been identified as one of the …
alkynes, commonly known as CuAAC or click chemistry, has been identified as one of the …
Carbohydrate-based macromolecular biomaterials
Carbohydrates are the most abundant and one of the most important biomacromolecules in
Nature. Except for energy-related compounds, carbohydrates can be roughly divided into …
Nature. Except for energy-related compounds, carbohydrates can be roughly divided into …
Targeting galectin-driven regulatory circuits in cancer and fibrosis
KV Mariño, AJ Cagnoni, DO Croci… - Nature Reviews Drug …, 2023 - nature.com
Galectins are a family of endogenous glycan-binding proteins that have crucial roles in a
broad range of physiological and pathological processes. As a group, these proteins use …
broad range of physiological and pathological processes. As a group, these proteins use …
Glycomimetics for the inhibition and modulation of lectins
Carbohydrates are essential mediators of many processes in health and disease. They
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …
Cu-catalyzed click reaction in carbohydrate chemistry
Cu (I)-catalyzed azide–alkyne 1, 3-dipolar cycloaddition (CuAAC), popularly known as the
“click reaction”, serves as the most potent and highly dependable tool for facile construction …
“click reaction”, serves as the most potent and highly dependable tool for facile construction …
Protein assembly: versatile approaches to construct highly ordered nanostructures
Nature endows life with a wide variety of sophisticated, synergistic, and highly functional
protein assemblies. Following Nature's inspiration to assemble protein building blocks into …
protein assemblies. Following Nature's inspiration to assemble protein building blocks into …
Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infection
The recent emergence of highly transmissible SARS-CoV-2 variants illustrates the urgent
need to better understand the molecular details of the virus binding to its host cell and to …
need to better understand the molecular details of the virus binding to its host cell and to …
Advancements in antimicrobial nanoscale materials and self-assembling systems
Antimicrobial resistance is directly responsible for more deaths per year than either
HIV/AIDS or malaria and is predicted to incur a cumulative societal financial burden of at …
HIV/AIDS or malaria and is predicted to incur a cumulative societal financial burden of at …
Synthesis of giant globular multivalent glycofullerenes as potent inhibitors in a model of Ebola virus infection
The use of multivalent carbohydrate compounds to block cell-surface lectin receptors is a
promising strategy to inhibit the entry of pathogens into cells and could lead to the discovery …
promising strategy to inhibit the entry of pathogens into cells and could lead to the discovery …
Novel Strategies for the Treatment of Pseudomonas aeruginosa Infections
S Wagner, R Sommer, S Hinsberger, C Lu… - Journal of medicinal …, 2016 - ACS Publications
Infections with Pseudomonas aeruginosa have become a concerning threat in hospital-
acquired infections and for cystic fibrosis patients. The major problem leading to high …
acquired infections and for cystic fibrosis patients. The major problem leading to high …