Acyl Glycosides through Stereospecific Glycosyl Cross-Coupling: Rapid Access to C(sp3)-Linked Glycomimetics
Replacement of a glycosidic bond with hydrolytically stable C–C surrogates is an efficient
strategy to access glycomimetics with improved physicochemical and pharmacological …
strategy to access glycomimetics with improved physicochemical and pharmacological …
Multivalent glycosheets for double light–driven therapy of multidrug‐resistant bacteria on wounds
XL Hu, L Chu, X Dong, GR Chen, T Tang… - Advanced Functional …, 2019 - Wiley Online Library
With the evergrowing threat posed by multidrug resistance of bacteria, the development of
effective antibacterial agents remains a global challenge. Infection with multidrug‐resistant …
effective antibacterial agents remains a global challenge. Infection with multidrug‐resistant …
Advances in glycosylation-mediated cancer-targeted drug delivery
Highlights•Aberrant tumor glycosylation has been used as a molecular target for cancer
therapy.•Advances in glycosylated strategies are allowing better targeted drug …
therapy.•Advances in glycosylated strategies are allowing better targeted drug …
Ultrasensitive detection of influenza viruses with a glycan-based impedimetric biosensor
A Hushegyi, D Pihíková, T Bertok, V Adam… - Biosensors and …, 2016 - Elsevier
An ultrasensitive impedimetric glycan-based biosensor for reliable and selective detection of
inactivated, but intact influenza viruses H3N2 was developed. Such glycan-based approach …
inactivated, but intact influenza viruses H3N2 was developed. Such glycan-based approach …
Neutralizing the Impact of the Virulence Factor LecA from Pseudomonas aeruginosa on Human Cells with New Glycomimetic Inhibitors
E Zahorska, F Rosato, K Stober… - Angewandte Chemie …, 2023 - Wiley Online Library
Bacterial adhesion, biofilm formation and host cell invasion of the ESKAPE pathogen
Pseudomonas aeruginosa require the tetravalent lectins LecA and LecB, which are …
Pseudomonas aeruginosa require the tetravalent lectins LecA and LecB, which are …
Rational-differential design of highly specific glycomimetic ligands: targeting DC-SIGN and excluding langerin recognition
V Porkolab, E Chabrol, N Varga, S Ordanini… - ACS chemical …, 2017 - ACS Publications
At the surface of dendritic cells, C-type lectin receptors (CLRs) allow the recognition of
carbohydrate-based PAMPS or DAMPS (pathogen-or danger-associated molecular …
carbohydrate-based PAMPS or DAMPS (pathogen-or danger-associated molecular …
Discovery of N-β-l-Fucosyl Amides as High-Affinity Ligands for the Pseudomonas aeruginosa Lectin LecB
P Mała, E Siebs, J Meiers, K Rox, A Varrot… - Journal of Medicinal …, 2022 - ACS Publications
The Gram-negative pathogen Pseudomonas aeruginosa causes severe infections mainly in
immunocompromised or cystic fibrosis patients and is able to resist antimicrobial treatments …
immunocompromised or cystic fibrosis patients and is able to resist antimicrobial treatments …
Pillar [5] arene‐based glycoclusters: Synthesis and multivalent binding to pathogenic bacterial lectins
K Buffet, I Nierengarten, N Galanos… - … A European Journal, 2016 - Wiley Online Library
The synthesis of pillar [5] arene‐based glycoclusters has been readily achieved by CuAAC
conjugations of azido‐and alkyne‐functionalized precursors. The lectin binding properties of …
conjugations of azido‐and alkyne‐functionalized precursors. The lectin binding properties of …
Potent glycosidase inhibition with heterovalent fullerenes: Unveiling the binding modes triggering multivalent inhibition
M Abellán Flos, MI García Moreno… - … A European Journal, 2016 - Wiley Online Library
Glycosidases are key enzymes in metabolism, pathogenic/antipathogenic mechanisms and
normal cellular functions. Recently, a novel approach for glycosidase inhibition that conveys …
normal cellular functions. Recently, a novel approach for glycosidase inhibition that conveys …
Design of glycopolymers carrying sialyl oligosaccharides for controlling the interaction with the influenza virus
We designed glycopolymers carrying sialyl oligosaccharides by “post-click” chemistry and
evaluated the interaction with the influenza virus. The glycopolymer structures were …
evaluated the interaction with the influenza virus. The glycopolymer structures were …