Depletion of CD8+ T cells enhances airway remodelling in a rodent model of asthma

K Tsuchiya, S Isogai, M Tamaoka, N Inase… - …, 2009 - Wiley Online Library
Airway remodelling is induced by persistent airway inflammation and may lead to severe
asthma. T cells play a pivotal role in asthmatic airway inflammation but their role in …

High content cellular immune profiling reveals differences between rhesus monkeys and men

I Magalhaes, NK Vudattu, RK Ahmed… - …, 2010 - Wiley Online Library
A better understanding of similarities and differences in the composition of the cellular
immune system in non‐human primates (NHPs) compared with human subjects will improve …

[PDF][PDF] A Bispecific gd T-cell Engager Targeting EGFR Activates a Potent Vg9Vd2 T cell–Mediated Immune Response against EGFR-Expressing Tumors

LA King, EC Toffoli, M Veth… - Cancer …, 2023 - scholarlypublications …
Vg9Vd2 T cells are effector cells with proven antitumor efficacy against a broad range of
cancers. This study aimed to assess the antitumor activity and safety of a bispecific antibody …

An explorative study on deep profiling of peripheral leukocytes to identify predictors for responsiveness to anti-tumour necrosis factor alpha therapies in ankylosing …

U Schulte-Wrede, T Sörensen, JR Grün, T Häupl… - Arthritis research & …, 2018 - Springer
Background Therapeutic targeting of tumour necrosis factor (TNF)-α is highly effective in
ankylosing spondylitis (AS) patients. However, since one-third of anti-TNF-treated AS …

Generation in vivo of peptide-specific cytotoxic T cells and presence of regulatory T cells during vaccination with hTERT (class I and II) peptide-pulsed DCs

MM Aloysius, AJ Mc Kechnie, RA Robins… - Journal of Translational …, 2009 - Springer
Background Optimal techniques for DC generation for immunotherapy in cancer are yet to
be established. Study aims were to evaluate:(i) DC activation/maturation milieu (TNF-α+/-IFN …

Functional TRPA1 Channels Regulate CD56dimCD16+ NK Cell Cytotoxicity against Tumor Cells

F Scopelliti, V Dimartino, C Cattani… - International Journal of …, 2023 - mdpi.com
Transient receptor potential ankyrin 1 (TRPA1) channels are expressed on the surface of
different cell types, including immune cells. However, TRPA1's role in the context of innate …

High‐Resolution Profiling of Human Vocal Fold Cellular Landscapes With Single‐Nuclei RNA Sequencing

BM Laitman, D Charytonowicz, AJ Zhu… - The …, 2024 - Wiley Online Library
Introduction The function of the vocal folds (VFs) is determined by the phenotype,
abundance, and distribution of differentiated cells within specific microenvironments …

Up-regulation of CX3CR1 on tonsillar CD8-positive cells in patients with IgA nephropathy

R Otaka, M Takahara, S Ueda, T Nagato, K Kishibe… - Human Immunology, 2017 - Elsevier
Although tonsillectomy are used as therapeutic options to prevent chronic renal failure in IgA
nephropathy (IgAN) patients, the relationship between IgAN and tonsils is not fully proved by …

The effects of age and latent cytomegalovirus infection on NK‐cell phenotype and exercise responsiveness in man

AB Bigley, G Spielmann, N Agha… - … medicine and cellular …, 2015 - Wiley Online Library
The redeployment of NK‐cells in response to an acute bout of exercise is thought to be an
integral component of the “fight‐or‐flight” response, preparing the body for potential injury or …

Effect of cocoa-enriched diets on lymphocytes involved in adjuvant arthritis in rats

S Ramos-Romero, FJ Pérez-Cano… - British journal of …, 2012 - cambridge.org
Cocoa and its flavonoids have potential anti-inflammatory properties in vitro and in acute
inflammation models in vivo. The aim of the present study was to ascertain the effects of two …