Beyond the bone: Bone morphogenetic protein signaling in adipose tissue

AM Blázquez‐Medela, M Jumabay… - Obesity …, 2019 - Wiley Online Library
The bone morphogenetic proteins (BMPs) belong to the same superfamily as related to
transforming growth factor β (TGFβ), growth and differentiation factors (GDFs), and activins …

Potential functions of the BMP family in bone, obesity, and glucose metabolism

Y Chen, B Ma, X Wang, X Zha, C Sheng… - Journal of diabetes …, 2021 - Wiley Online Library
Characteristic bone metabolism was observed in obesity and diabetes with controversial
conclusions. Type 2 diabetes (T2DM) and obesity may manifest increased bone mineral …

Ultrasound triggered topical delivery of Bmp7 mRNA for white fat browning induction via engineered smart exosomes

Y Guo, Z Wan, P Zhao, M Wei, Y Liu, T Bu… - Journal of …, 2021 - Springer
Background Efficient and topical delivery of drugs is essential for maximized efficacy and
minimized toxicity. In this study, we aimed to design an exosome-based drug delivery …

Brown adipose tissue: updates in cellular and molecular biology

TCL Bargut, MB Aguila, CA Mandarim-de-Lacerda - Tissue and Cell, 2016 - Elsevier
Brown adipose tissue (BAT) is mainly composed of adipocytes, it is highly vascularized and
innervated, and can be activated in adult humans. Brown adipocytes are responsible for …

MECHANISMS IN ENDOCRINOLOGY: Human brown adipose tissue as a therapeutic target: warming up or cooling down?

BT McNeill, KJ Suchacki… - European Journal of …, 2021 - academic.oup.com
Excessive accumulation of white adipose tissue leads to obesity and its associated
metabolic health consequences such as type 2 diabetes and cardiovascular disease …

The influence of ambient temperature on adipose tissue homeostasis, metabolic diseases and cancers

RP Ginting, JM Lee, MW Lee - Cells, 2023 - mdpi.com
Adipose tissue is a recognized energy storage organ during excessive energy intake and an
endocrine and thermoregulator, which interacts with other tissues to regulate systemic …

[HTML][HTML] Biology of bone morphogenetic protein in bone repair and regeneration: A role for autologous blood coagulum as carrier

TK Sampath, S Vukicevic - Bone, 2020 - Elsevier
BMPs were purified from demineralized bone matrix based on their ability to induce new
bone in vivo and they represent a large member of the TGF-β superfamily of proteins. BMPs …

Immune modulation of brown (ing) adipose tissue in obesity

SM van den Berg, AD van Dam, PCN Rensen… - Endocrine …, 2017 - academic.oup.com
Obesity is associated with a variety of medical conditions such as type 2 diabetes and
cardiovascular diseases and is therefore responsible for high morbidity and mortality rates …

Adipose tissue plasticity and the pleiotropic roles of BMP signaling

S Qian, Y Tang, QQ Tang - Journal of Biological Chemistry, 2021 - ASBMB
Adipose tissues, including white, beige, and brown adipose tissue, have evolved to be
highly dynamic organs. Adipose tissues undergo profound changes during development …

Bone morphogenetic proteins in inflammation, glucose homeostasis and adipose tissue energy metabolism

L Grgurevic, GL Christensen, TJ Schulz… - Cytokine & growth factor …, 2016 - Elsevier
Bore morphogenetic proteins (BMPs) are members of the transforming growth factor (TGF)-β
superfamily, a group of secreted proteins that regulate embryonic development. This review …