Targeting orexin receptors: Recent advances in the development of subtype selective or dual ligands for the treatment of neuropsychiatric disorders

A Bonifazi, F Del Bello, G Giorgioni… - Medicinal Research …, 2023 - Wiley Online Library
Orexin‐A and orexin‐B, also named hypocretin‐1 and hypocretin‐2, are two hypothalamic
neuropeptides highly conserved across mammalian species. Their effects are mediated by …

[HTML][HTML] The short-chain fatty acid acetate modulates orexin/hypocretin neurons: A novel mechanism in gut-brain axis regulation of energy homeostasis and feeding

N Forte, B Marfella, A Nicois, L Palomba, D Paris… - Biochemical …, 2024 - Elsevier
The short-chain fatty acids (SCFAs) acetate, propionate and butyrate, the major products of
intestinal microbial fermentation of dietary fibres, are involved in fine-tuning brain functions …

The hypothalamic neuropeptide, QRFP, regulates high fat diet intake in female Long-Evans rats following ovariectomy

CT Martin, SD Primeaux - Peptides, 2023 - Elsevier
Obesity rates in women continue to increase throughout the lifespan and obesity-related
comorbidities are prevalent in women in estrogen deficiency. The hypothalamic …

Editorial of Special Issue “Advances in Neuropeptide Biology”

G Maugeri, V D'Agata - Applied Sciences, 2022 - mdpi.com
This editorial aims to summarize the contents of the six scientific papers included in the
Special Issue “Advances in Neuropeptide Biology”. Neuropeptides are small chains of …