Disease modification in inflammatory skin disorders: opportunities and challenges

T Bieber - Nature Reviews Drug Discovery, 2023 - nature.com
Progress in understanding of the mechanisms underlying chronic inflammatory skin
disorders, such as atopic dermatitis and psoriasis vulgaris, has led to new treatment options …

Metabolic syndrome and psoriasis: mechanisms and future directions

Y Hao, Y Zhu, S Zou, P Zhou, Y Hu, Q Zhao… - Frontiers in …, 2021 - frontiersin.org
Psoriasis is an immune-mediated systemic disease with associated comorbidities, including
metabolic syndrome (MetS) which contributes substantially to premature mortality in patients …

EuroGuiDerm Guideline on the systemic treatment of Psoriasis vulgaris–Part 1: treatment and monitoring recommendations

A Nast, C Smith, PI Spuls, G Avila Valle… - Journal of the …, 2020 - Wiley Online Library
This evidence‐and consensus‐based guideline on the treatment of psoriasis vulgaris was
developed following the EuroGuiDerm Guideline and Consensus Statement Development …

EuroGuiDerm Guideline on the systemic treatment of Psoriasis vulgaris–Part 2: specific clinical and comorbid situations

A Nast, C Smith, PI Spuls, G Avila Valle… - Journal of the …, 2021 - Wiley Online Library
This evidence‐and consensus‐based guideline on the treatment of psoriasis vulgaris was
developed following the EuroGuiDerm Guideline and Consensus Statement Development …

Impact of previous biologic use and body weight on the effectiveness of guselkumab in moderate-to-severe plaque psoriasis: a real-world practice

YT Hung, YJ Lin, HY Chiu… - Therapeutic Advances in …, 2021 - journals.sagepub.com
Background: Real-life data on patients with psoriasis treated with guselkumab are few and
are needed to compare with trial-based data. We investigated the effect of clinical factors on …

[HTML][HTML] Predictors of response to biologics in patients with moderate-to-severe psoriasis: a Danish nationwide cohort study

CW Schwarz, L Nikolai, MK Rasmussen… - Acta Dermato …, 2021 - ncbi.nlm.nih.gov
Identifying patient characteristics associated with achieving treatment response to biologics
in patients with psoriasis could prevent expensive switching between biologics. The aim of …

Efficacy of guselkumab versus secukinumab in subpopulations of patients with moderate-to-severe plaque psoriasis: results from the ECLIPSE study

A Blauvelt, AW Armstrong, RG Langley… - Journal of …, 2022 - Taylor & Francis
Purpose Guselkumab, an interleukin (IL)-23 inhibitor, effectively treats moderate-to-severe
plaque psoriasis. Materials and methods ECLIPSE, was a Phase 3, multicenter, 56-week …

Clinical efficacy and safety of psoriasis treatments in patients with concomitant metabolic syndrome: a narrative review

JF Merola, A Kavanaugh, MG Lebwohl… - Dermatology and …, 2022 - Springer
Metabolic syndrome (MetS) is well recognized as a frequent comorbidity of psoriasis with
important implications for efficacy and safety of psoriasis treatment. The presence of …

Correlation between change in psoriasis area and severity index and dermatology life quality index in patients with psoriasis: pooled analysis from four phase 3 …

K Houghton, D Patil, B Gomez, SR Feldman - Dermatology and Therapy, 2021 - Springer
Abstract Introduction Patients with psoriasis (PsO) experience impaired health-related
quality of life due to physical and psychosocial burdens. The objective of this study was to …

Changes in metabolic parameters in psoriatic patients treated with secukinumab

HN Wang, YH Huang - Therapeutic advances in chronic …, 2020 - journals.sagepub.com
Background: Psoriasis is associated with cardiovascular disease and metabolic syndrome
but the effects of interleukin (IL)-17A inhibitor treatment on metabolic parameters are …