Abstract Platelet factor 4 (PF4) combines with heparin to form an antigen that could produce
IgG antibodies and participate in heparin-induced thrombocytopenia (HIT). PF4 has …

Alzheimer's disease (AD) is a rapidly growing global concern due to a consistent rise of the
prevalence of dementia which is mainly caused by the aging population worldwide. An early …

Aging is a complex and multifaceted process involving a variety of interrelated molecular
mechanisms and cellular systems. Phenotypically, the biological aging process is …

Background Diabetic peripheral neuropathy (DPN) is one of the most common
complications of diabetes and the main cause of non-traumatic amputation, with no ideal …

Acute myeloid leukemia (AML) is an aging-related and heterogeneous hematopoietic
malignancy. In this study, a total of 1,474 newly diagnosed AML patients with RNA …

Age-related loss of brain function has been seen as inevitable, yet recent work leveraging
the systemic environment challenges this notion. Schroer et al. demonstrate that youth …

In Canada and worldwide, the elderly population (ie, individuals> 65 years of age) is
increasing disproportionately relative to the total population. This is expected to have a …

Despite substantial evidence emphasizing the pleiotropic benefits of exercise for the
prevention and treatment of various diseases, the underlying biological mechanisms have …

Understanding the regulatory mechanisms facilitating hematopoietic stem cell (HSC)
specification during embryogenesis is important for the generation of HSCs in vitro …

Exercise has the unique aptitude to benefit overall health of body and brain. Evidence
indicates that the effects of exercise can be saved in the epigenome for considerable time to …